Periosteal stem cells: Research progress and application prospect
The periosteum, a connective tissue layer covering bone surfaces, possesses excellent bone regeneration capabilities and serves as the primary reservoir of stem cells for bone repair. This review summarizes the organizational structure and physiological functions of the periosteum, with a focus on t...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Oral and Maxillofacial Surgery
2025-06-01
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| Series: | Kouqiang hemian waike zazhi |
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| Online Access: | https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2025.03.010 |
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| author | YI Zumu DENG Chen MAN Yi |
| author_facet | YI Zumu DENG Chen MAN Yi |
| author_sort | YI Zumu |
| collection | DOAJ |
| description | The periosteum, a connective tissue layer covering bone surfaces, possesses excellent bone regeneration capabilities and serves as the primary reservoir of stem cells for bone repair. This review summarizes the organizational structure and physiological functions of the periosteum, with a focus on the cell markers and biological characteristics of periosteal stem cells (PSCs). In recent years, utilizing techniques such as single-cell sequencing, different subsets have been identified, and their good proliferation and multilineage differentiation potential have been revealed. The biological functions of PSCs are regulated by complex molecular signals. There may be interactions between different signals to orchestrate periosteal stem cell activities. Additionally, this review outlines the prospective applications of PSCs in bone tissue engineering. Future investigations should prioritize exploring the heterogeneity of PSCs and exploring the application of different PSCs subsets in both tissue engineering and clinical settings. |
| format | Article |
| id | doaj-art-08fe1a2d615045e1ae1021e4019f6eec |
| institution | Kabale University |
| issn | 1005-4979 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Editorial Office of Journal of Oral and Maxillofacial Surgery |
| record_format | Article |
| series | Kouqiang hemian waike zazhi |
| spelling | doaj-art-08fe1a2d615045e1ae1021e4019f6eec2025-08-25T06:12:15ZzhoEditorial Office of Journal of Oral and Maxillofacial SurgeryKouqiang hemian waike zazhi1005-49792025-06-0135322723210.12439/kqhm.1005-4979.2025.03.010Periosteal stem cells: Research progress and application prospectYI Zumu0DENG Chen1MAN Yi2State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaThe periosteum, a connective tissue layer covering bone surfaces, possesses excellent bone regeneration capabilities and serves as the primary reservoir of stem cells for bone repair. This review summarizes the organizational structure and physiological functions of the periosteum, with a focus on the cell markers and biological characteristics of periosteal stem cells (PSCs). In recent years, utilizing techniques such as single-cell sequencing, different subsets have been identified, and their good proliferation and multilineage differentiation potential have been revealed. The biological functions of PSCs are regulated by complex molecular signals. There may be interactions between different signals to orchestrate periosteal stem cell activities. Additionally, this review outlines the prospective applications of PSCs in bone tissue engineering. Future investigations should prioritize exploring the heterogeneity of PSCs and exploring the application of different PSCs subsets in both tissue engineering and clinical settings.https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2025.03.010periosteumstem cellsbone regenerationbone tissue engineering |
| spellingShingle | YI Zumu DENG Chen MAN Yi Periosteal stem cells: Research progress and application prospect Kouqiang hemian waike zazhi periosteum stem cells bone regeneration bone tissue engineering |
| title | Periosteal stem cells: Research progress and application prospect |
| title_full | Periosteal stem cells: Research progress and application prospect |
| title_fullStr | Periosteal stem cells: Research progress and application prospect |
| title_full_unstemmed | Periosteal stem cells: Research progress and application prospect |
| title_short | Periosteal stem cells: Research progress and application prospect |
| title_sort | periosteal stem cells research progress and application prospect |
| topic | periosteum stem cells bone regeneration bone tissue engineering |
| url | https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2025.03.010 |
| work_keys_str_mv | AT yizumu periostealstemcellsresearchprogressandapplicationprospect AT dengchen periostealstemcellsresearchprogressandapplicationprospect AT manyi periostealstemcellsresearchprogressandapplicationprospect |