Circadian activity and sleep architecture in autism spectrum disorder mouse model with Chd8 mutation
Individuals with autism spectrum disorder (ASD) frequently experience sleep disturbances, including difficulties in sleep initiation, reduced total sleep time, and excessive daytime sleepiness. Among them, those carrying mutations in the CHD8, a high-penetrance ASD risk gene, often exhibit both core...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Sleep |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frsle.2025.1614100/full |
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| author | Jiahui Yu Jiahui Yu Jiahui Yu Norie Deki-Arima Norie Deki-Arima Yuki C. Saito Yuki C. Saito Naoki Furutani Masaaki Nishiyama Masaaki Nishiyama Keiichi I. Nakayama Yasutaka Niwa Arisa Hirano Arisa Hirano Takeshi Sakurai Takeshi Sakurai Takeshi Sakurai |
| author_facet | Jiahui Yu Jiahui Yu Jiahui Yu Norie Deki-Arima Norie Deki-Arima Yuki C. Saito Yuki C. Saito Naoki Furutani Masaaki Nishiyama Masaaki Nishiyama Keiichi I. Nakayama Yasutaka Niwa Arisa Hirano Arisa Hirano Takeshi Sakurai Takeshi Sakurai Takeshi Sakurai |
| author_sort | Jiahui Yu |
| collection | DOAJ |
| description | Individuals with autism spectrum disorder (ASD) frequently experience sleep disturbances, including difficulties in sleep initiation, reduced total sleep time, and excessive daytime sleepiness. Among them, those carrying mutations in the CHD8, a high-penetrance ASD risk gene, often exhibit both core ASD symptoms and pronounced sleep abnormalities. However, detailed evaluations of sleep architecture and circadian activity in this population remain limited. In this study, we characterized the daily sleep patterns of Chd8 heterozygous knockout mice of both sexes, an established ASD model, using electroencephalography (EEG)/electromyography (EMG) recordings. Chd8 knockout mice exhibited reduced wakefulness and increased rapid eye movement (REM) sleep duration during the dark phase, along with disruption of normal daily REM sleep fluctuations. Furthermore, analysis of REM latency distributions revealed a reduction in short-latency REM bouts (i.e., <150 seconds) during the light phase. Chd8 knockout also showed reduced locomotor activity at night. These findings provide new insights into the sleep phenotypes associated with CHD8-related ASD and may help elucidate the underlying neurobiological mechanisms of sleep disturbances in this condition. |
| format | Article |
| id | doaj-art-08f8580daae749169a7d0799dffa1a22 |
| institution | DOAJ |
| issn | 2813-2890 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Sleep |
| spelling | doaj-art-08f8580daae749169a7d0799dffa1a222025-08-20T02:57:35ZengFrontiers Media S.A.Frontiers in Sleep2813-28902025-08-01410.3389/frsle.2025.16141001614100Circadian activity and sleep architecture in autism spectrum disorder mouse model with Chd8 mutationJiahui Yu0Jiahui Yu1Jiahui Yu2Norie Deki-Arima3Norie Deki-Arima4Yuki C. Saito5Yuki C. Saito6Naoki Furutani7Masaaki Nishiyama8Masaaki Nishiyama9Keiichi I. Nakayama10Yasutaka Niwa11Arisa Hirano12Arisa Hirano13Takeshi Sakurai14Takeshi Sakurai15Takeshi Sakurai16International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, JapanDegree Program in Comprehensive Human Sciences, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, JapanInstitute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, JapanInternational Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, JapanInstitute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, JapanInternational Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, JapanInstitute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, JapanDepartment of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanSocial Brain Development Research Unit, Next Generation Medical Development Research Core, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Ishikawa, JapanDepartment of Histology and Cell Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, JapanAnticancer Strategies Laboratory, Advanced Research Initiative, Institute of Science Tokyo, Tokyo, JapanDepartment of Pharmacology, Biomedical Research Center, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, JapanInternational Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, JapanInstitute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, JapanInternational Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba, Tsukuba, Ibaraki, JapanInstitute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, JapanLife Science Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, JapanIndividuals with autism spectrum disorder (ASD) frequently experience sleep disturbances, including difficulties in sleep initiation, reduced total sleep time, and excessive daytime sleepiness. Among them, those carrying mutations in the CHD8, a high-penetrance ASD risk gene, often exhibit both core ASD symptoms and pronounced sleep abnormalities. However, detailed evaluations of sleep architecture and circadian activity in this population remain limited. In this study, we characterized the daily sleep patterns of Chd8 heterozygous knockout mice of both sexes, an established ASD model, using electroencephalography (EEG)/electromyography (EMG) recordings. Chd8 knockout mice exhibited reduced wakefulness and increased rapid eye movement (REM) sleep duration during the dark phase, along with disruption of normal daily REM sleep fluctuations. Furthermore, analysis of REM latency distributions revealed a reduction in short-latency REM bouts (i.e., <150 seconds) during the light phase. Chd8 knockout also showed reduced locomotor activity at night. These findings provide new insights into the sleep phenotypes associated with CHD8-related ASD and may help elucidate the underlying neurobiological mechanisms of sleep disturbances in this condition.https://www.frontiersin.org/articles/10.3389/frsle.2025.1614100/fullautism spectrum disorder (ASD)sleepEEGCHD8Chd8 knockout mice |
| spellingShingle | Jiahui Yu Jiahui Yu Jiahui Yu Norie Deki-Arima Norie Deki-Arima Yuki C. Saito Yuki C. Saito Naoki Furutani Masaaki Nishiyama Masaaki Nishiyama Keiichi I. Nakayama Yasutaka Niwa Arisa Hirano Arisa Hirano Takeshi Sakurai Takeshi Sakurai Takeshi Sakurai Circadian activity and sleep architecture in autism spectrum disorder mouse model with Chd8 mutation Frontiers in Sleep autism spectrum disorder (ASD) sleep EEG CHD8 Chd8 knockout mice |
| title | Circadian activity and sleep architecture in autism spectrum disorder mouse model with Chd8 mutation |
| title_full | Circadian activity and sleep architecture in autism spectrum disorder mouse model with Chd8 mutation |
| title_fullStr | Circadian activity and sleep architecture in autism spectrum disorder mouse model with Chd8 mutation |
| title_full_unstemmed | Circadian activity and sleep architecture in autism spectrum disorder mouse model with Chd8 mutation |
| title_short | Circadian activity and sleep architecture in autism spectrum disorder mouse model with Chd8 mutation |
| title_sort | circadian activity and sleep architecture in autism spectrum disorder mouse model with chd8 mutation |
| topic | autism spectrum disorder (ASD) sleep EEG CHD8 Chd8 knockout mice |
| url | https://www.frontiersin.org/articles/10.3389/frsle.2025.1614100/full |
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