The role of Nrf2 transcription factors in various physiological and pathological states
Since its first report in 1994, understanding of the nuclear factor erythroid 2-related factor 2 (Nrf2) has continued to grow. Initially recognized for its role in cellular response to oxidative stress, Nrf2 is now known to be involved in a variety of regulatory process, including metabolic regulat...
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| Format: | Article |
| Language: | English |
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Indonesian Society for Biochemistry and Molecular Biology
2024-07-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/103 |
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| author | Deasyka Yastani Sri Widia A Jusman |
| author_facet | Deasyka Yastani Sri Widia A Jusman |
| author_sort | Deasyka Yastani |
| collection | DOAJ |
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Since its first report in 1994, understanding of the nuclear factor erythroid 2-related factor 2 (Nrf2) has continued to grow. Initially recognized for its role in cellular response to oxidative stress, Nrf2 is now known to be involved in a variety of regulatory process, including metabolic regulation, autophagy, protein homeostasis (proteostasis), and mitochondrial biogenesis. The expression of Nrf2 target genes is highly dependent on stimulus activation and interactions with transcription factors, activators, and repressors. Nrf2 activation serves as a defense mechanism under physiological conditions, but in the context of cancer, it can trigger the development of cancer cells due to its complex roles. Nrf2 is strongly associated with the onset and development of many diseases, including those caused by metabolic disorders and inflammation. Understanding Nrf2's diverse functions offers valuable insights into disease pathogenesis and potential therapeutic approaches. This review explores the pleiotropic role of Nrf2 regulation.
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| format | Article |
| id | doaj-art-08f601088d124e2f8c6d7b1307c8d9d1 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-08f601088d124e2f8c6d7b1307c8d9d12025-02-08T03:04:51ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222024-07-016210.32889/actabioina.103The role of Nrf2 transcription factors in various physiological and pathological statesDeasyka Yastani0Sri Widia A Jusman1Department of Biochemistry, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaCenter of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia Since its first report in 1994, understanding of the nuclear factor erythroid 2-related factor 2 (Nrf2) has continued to grow. Initially recognized for its role in cellular response to oxidative stress, Nrf2 is now known to be involved in a variety of regulatory process, including metabolic regulation, autophagy, protein homeostasis (proteostasis), and mitochondrial biogenesis. The expression of Nrf2 target genes is highly dependent on stimulus activation and interactions with transcription factors, activators, and repressors. Nrf2 activation serves as a defense mechanism under physiological conditions, but in the context of cancer, it can trigger the development of cancer cells due to its complex roles. Nrf2 is strongly associated with the onset and development of many diseases, including those caused by metabolic disorders and inflammation. Understanding Nrf2's diverse functions offers valuable insights into disease pathogenesis and potential therapeutic approaches. This review explores the pleiotropic role of Nrf2 regulation. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/103Nrf2oxidative stressmetabolic regulationproteostasistranscription factor |
| spellingShingle | Deasyka Yastani Sri Widia A Jusman The role of Nrf2 transcription factors in various physiological and pathological states Acta Biochimica Indonesiana Nrf2 oxidative stress metabolic regulation proteostasis transcription factor |
| title | The role of Nrf2 transcription factors in various physiological and pathological states |
| title_full | The role of Nrf2 transcription factors in various physiological and pathological states |
| title_fullStr | The role of Nrf2 transcription factors in various physiological and pathological states |
| title_full_unstemmed | The role of Nrf2 transcription factors in various physiological and pathological states |
| title_short | The role of Nrf2 transcription factors in various physiological and pathological states |
| title_sort | role of nrf2 transcription factors in various physiological and pathological states |
| topic | Nrf2 oxidative stress metabolic regulation proteostasis transcription factor |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/103 |
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