The Mechanisms of Pharmacological Preconditioning of the Brain and the Comparative Efficacy of the Drugs — Direct- and Indirect-Acting Glycogen Synthase Kinase-3β Inhibitors: Experimental Study

The Mechanisms of Pharmacological Preconditioning of the Brain and the Comparative Efficacy of the Drugs — Direct- and Indirect-Acting Glycogen Synthase Kinase-3β Inhibitors: Experimental Study

Objective: to investigate the activity of sevoflurane, dalargin, and lithium chloride in protecting the rat brain from total ischemia/reperfusion and to define whether the GSK=3^ deposphorylation contributes to the mechanism of pharmacological preconditioning. Materials and methods. Experiments were...

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Bibliographic Details
Main Authors: V. V. Likhvantsev, O. A. Grebenchikov, K. Yu. Borisov, V. L., Shaibakova, A. A. Shaposhnikov, R. A. Cherpakov, E. V. Shmeleva
Format: Article
Language:English
Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 2012-12-01
Series:Общая реаниматология
Subjects:
литий
даларгин
севофлуран
прекондиционирование
головной мозг.
Online Access:https://www.reanimatology.com/rmt/article/view/175
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