Effect of Chromium Picolinate and Chromium Nanoparticles Added to Low- or High-Fat Diets on Chromium Biodistribution and the Blood Level of Selected Minerals in Rats
The metabolism of chromium (Cr), calcium (Ca), phosphorus (P), iron (Fe), copper (Cu), and zinc (Zn) is interconnected, and their deficiency or excessive accumulation may lead to various disturbances, including anemia and diabetes. The current research was undertaken to determine whether low-fat or...
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2022-07-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://journal.pan.olsztyn.pl/Effect-of-Chromium-Picolinate-and-Chromium-Nanoparticles-Added-to-Low-or-High-Fat,151750,0,2.html |
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| author | Anna Stępniowska Jerzy Juśkiewicz Krzysztof Tutaj Joanna Fotschki Bartosz Fotschki Katarzyna Ognik |
| author_facet | Anna Stępniowska Jerzy Juśkiewicz Krzysztof Tutaj Joanna Fotschki Bartosz Fotschki Katarzyna Ognik |
| author_sort | Anna Stępniowska |
| collection | DOAJ |
| description | The metabolism of chromium (Cr), calcium (Ca), phosphorus (P), iron (Fe), copper (Cu), and zinc (Zn) is interconnected, and their deficiency or excessive accumulation may lead to various disturbances, including anemia and diabetes. The current research was undertaken to determine whether low-fat or high-fat diets with the Cr(III) addition in the form of picolinate (CrPic) or nanoparticles (CrNPs) have an interactive effect on the retention and accumulation of this element in organs and the content of P, Ca, Fe, Cu and Zn in the blood plasma of rats. The experiment was performed using 48 outbred male Wistar rats fed a low-fat or high-fat semi-purified rat diet with dietary addition of chromium at a dose of 0.3 mg/kg body weight. The obtained results point to the paramount importance of the dietary Cr form on the excretion pattern of this microelement. It has been found that CrNPs were to a greater extent excreted from the rat’s body via urine and feces in comparison to CrPic, as indicated by the values of the Cr retention index (44.4 vs . 65.9%, respectively). The additional dietary Cr, irrespective of its form and diet type, was not accumulated in the analyzed internal organs, i.e. brain, spleen, kidneys, liver, thigh bone, and thigh muscle. It should be stressed that dietary CrPic, unlike CrNPs, added to the high-fat diet adversely reduced plasma concentration of vital minerals in comparison to the levels observed in rats fed the low-fat diet, i.e. Zn (60.5 vs. 69.9 µM), Cu (13.6 vs. 15.7 µM), and P (1.12 vs. 1.30 µM). In turn, the CrNPs, but not CrPic, added to the high-fat diet decreased plasma Fe level (1.41 vs. 2.43 µM). |
| format | Article |
| id | doaj-art-08ef91278a4340cbaefae71d1034b8e7 |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-08ef91278a4340cbaefae71d1034b8e72025-02-02T05:10:54ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072022-07-0172322923810.31883/pjfns/151750151750Effect of Chromium Picolinate and Chromium Nanoparticles Added to Low- or High-Fat Diets on Chromium Biodistribution and the Blood Level of Selected Minerals in RatsAnna Stępniowska0https://orcid.org/0000-0003-2424-8935Jerzy Juśkiewicz1https://orcid.org/0000-0003-0068-5970Krzysztof Tutaj2https://orcid.org/0000-0002-3742-3715Joanna Fotschki3https://orcid.org/0000-0002-0116-0909Bartosz Fotschki4https://orcid.org/0000-0002-9727-7481Katarzyna Ognik5https://orcid.org/0000-0003-4393-4092Department of Biochemistry and Toxicology, Faculty of Animal Science and Bioeconomy, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, PolandDepartment of Biological Functions of Food, Division of Food Science, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, PolandDepartment of Biochemistry and Toxicology, Faculty of Animal Science and Bioeconomy, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, PolandDepartment of Immunology and Food Microbiology, Division of Food Science, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, PolandDepartment of Biological Functions of Food, Division of Food Science, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, PolandDepartment of Biochemistry and Toxicology, Faculty of Animal Science and Bioeconomy, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, PolandThe metabolism of chromium (Cr), calcium (Ca), phosphorus (P), iron (Fe), copper (Cu), and zinc (Zn) is interconnected, and their deficiency or excessive accumulation may lead to various disturbances, including anemia and diabetes. The current research was undertaken to determine whether low-fat or high-fat diets with the Cr(III) addition in the form of picolinate (CrPic) or nanoparticles (CrNPs) have an interactive effect on the retention and accumulation of this element in organs and the content of P, Ca, Fe, Cu and Zn in the blood plasma of rats. The experiment was performed using 48 outbred male Wistar rats fed a low-fat or high-fat semi-purified rat diet with dietary addition of chromium at a dose of 0.3 mg/kg body weight. The obtained results point to the paramount importance of the dietary Cr form on the excretion pattern of this microelement. It has been found that CrNPs were to a greater extent excreted from the rat’s body via urine and feces in comparison to CrPic, as indicated by the values of the Cr retention index (44.4 vs . 65.9%, respectively). The additional dietary Cr, irrespective of its form and diet type, was not accumulated in the analyzed internal organs, i.e. brain, spleen, kidneys, liver, thigh bone, and thigh muscle. It should be stressed that dietary CrPic, unlike CrNPs, added to the high-fat diet adversely reduced plasma concentration of vital minerals in comparison to the levels observed in rats fed the low-fat diet, i.e. Zn (60.5 vs. 69.9 µM), Cu (13.6 vs. 15.7 µM), and P (1.12 vs. 1.30 µM). In turn, the CrNPs, but not CrPic, added to the high-fat diet decreased plasma Fe level (1.41 vs. 2.43 µM).http://journal.pan.olsztyn.pl/Effect-of-Chromium-Picolinate-and-Chromium-Nanoparticles-Added-to-Low-or-High-Fat,151750,0,2.htmlmineralschromiumnanoparticleshigh-fat diet |
| spellingShingle | Anna Stępniowska Jerzy Juśkiewicz Krzysztof Tutaj Joanna Fotschki Bartosz Fotschki Katarzyna Ognik Effect of Chromium Picolinate and Chromium Nanoparticles Added to Low- or High-Fat Diets on Chromium Biodistribution and the Blood Level of Selected Minerals in Rats Polish Journal of Food and Nutrition Sciences minerals chromium nanoparticles high-fat diet |
| title | Effect of Chromium Picolinate and Chromium Nanoparticles Added to Low- or High-Fat Diets on Chromium Biodistribution and the Blood Level of Selected Minerals in Rats |
| title_full | Effect of Chromium Picolinate and Chromium Nanoparticles Added to Low- or High-Fat Diets on Chromium Biodistribution and the Blood Level of Selected Minerals in Rats |
| title_fullStr | Effect of Chromium Picolinate and Chromium Nanoparticles Added to Low- or High-Fat Diets on Chromium Biodistribution and the Blood Level of Selected Minerals in Rats |
| title_full_unstemmed | Effect of Chromium Picolinate and Chromium Nanoparticles Added to Low- or High-Fat Diets on Chromium Biodistribution and the Blood Level of Selected Minerals in Rats |
| title_short | Effect of Chromium Picolinate and Chromium Nanoparticles Added to Low- or High-Fat Diets on Chromium Biodistribution and the Blood Level of Selected Minerals in Rats |
| title_sort | effect of chromium picolinate and chromium nanoparticles added to low or high fat diets on chromium biodistribution and the blood level of selected minerals in rats |
| topic | minerals chromium nanoparticles high-fat diet |
| url | http://journal.pan.olsztyn.pl/Effect-of-Chromium-Picolinate-and-Chromium-Nanoparticles-Added-to-Low-or-High-Fat,151750,0,2.html |
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