Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported
Hydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to subli...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/319086 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565419677843456 |
|---|---|
| author | Toufik Mahfood Haddad Muhammad Sarfraz Nawaz Ahmed S. Abuzaid Smrithy Upadhyay Pallavi Bellamkonda Aryan N. Mooss |
| author_facet | Toufik Mahfood Haddad Muhammad Sarfraz Nawaz Ahmed S. Abuzaid Smrithy Upadhyay Pallavi Bellamkonda Aryan N. Mooss |
| author_sort | Toufik Mahfood Haddad |
| collection | DOAJ |
| description | Hydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. Her medications included hydrochlorothiazide (HCTZ) which was started three months ago for uncontrolled hypertension. Significant laboratory parameters included erythrocyte sedimentation rate (ESR) of 47 mm/hr and peak troponin of 0.26 ng/mL. Transthoracic echocardiogram (TTE) revealed preserved ejection fraction with no segmental wall motion abnormalities; however, it showed moderate pericardial effusion without tamponade physiology. We hypothesize that this myopericarditis could be due to HCTZ allergic reaction after all other common etiologies have been ruled out. There is a scarcity of the literature regarding HCTZ as an etiology for pericardial disease, with only one case reported as presumed hydrochlorothiazide-induced pericardial effusion. Management involves discontinuation of HCTZ and starting anti-inflammatory therapy. |
| format | Article |
| id | doaj-art-08ee126d4807492ead236d0086abd7dd |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-08ee126d4807492ead236d0086abd7dd2025-02-03T01:07:44ZengWileyCase Reports in Medicine1687-96271687-96352015-01-01201510.1155/2015/319086319086Probable Hydrochlorothiazide-Induced Myopericarditis: First Case ReportedToufik Mahfood Haddad0Muhammad Sarfraz Nawaz1Ahmed S. Abuzaid2Smrithy Upadhyay3Pallavi Bellamkonda4Aryan N. Mooss5Department of Internal Medicine, CHI Health Creighton University Medical Center, Creighton University School of Medicine, 601 North 30th Street, No. 5850, Omaha, NE 68131, USADepartment of Internal Medicine, CHI Health Creighton University Medical Center, Creighton University School of Medicine, 601 North 30th Street, No. 5850, Omaha, NE 68131, USADepartment of Internal Medicine, CHI Health Creighton University Medical Center, Creighton University School of Medicine, 601 North 30th Street, No. 5850, Omaha, NE 68131, USADepartment of Internal Medicine, CHI Health Creighton University Medical Center, Creighton University School of Medicine, 601 North 30th Street, No. 5850, Omaha, NE 68131, USADepartment of Internal Medicine, CHI Health Creighton University Medical Center, Creighton University School of Medicine, 601 North 30th Street, No. 5850, Omaha, NE 68131, USADepartment of Internal Medicine, CHI Health Creighton University Medical Center, Creighton University School of Medicine, 601 North 30th Street, No. 5850, Omaha, NE 68131, USAHydrochlorothiazide has never been reported as a reason for myopericarditis. An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. Her medications included hydrochlorothiazide (HCTZ) which was started three months ago for uncontrolled hypertension. Significant laboratory parameters included erythrocyte sedimentation rate (ESR) of 47 mm/hr and peak troponin of 0.26 ng/mL. Transthoracic echocardiogram (TTE) revealed preserved ejection fraction with no segmental wall motion abnormalities; however, it showed moderate pericardial effusion without tamponade physiology. We hypothesize that this myopericarditis could be due to HCTZ allergic reaction after all other common etiologies have been ruled out. There is a scarcity of the literature regarding HCTZ as an etiology for pericardial disease, with only one case reported as presumed hydrochlorothiazide-induced pericardial effusion. Management involves discontinuation of HCTZ and starting anti-inflammatory therapy.http://dx.doi.org/10.1155/2015/319086 |
| spellingShingle | Toufik Mahfood Haddad Muhammad Sarfraz Nawaz Ahmed S. Abuzaid Smrithy Upadhyay Pallavi Bellamkonda Aryan N. Mooss Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported Case Reports in Medicine |
| title | Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported |
| title_full | Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported |
| title_fullStr | Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported |
| title_full_unstemmed | Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported |
| title_short | Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported |
| title_sort | probable hydrochlorothiazide induced myopericarditis first case reported |
| url | http://dx.doi.org/10.1155/2015/319086 |
| work_keys_str_mv | AT toufikmahfoodhaddad probablehydrochlorothiazideinducedmyopericarditisfirstcasereported AT muhammadsarfraznawaz probablehydrochlorothiazideinducedmyopericarditisfirstcasereported AT ahmedsabuzaid probablehydrochlorothiazideinducedmyopericarditisfirstcasereported AT smrithyupadhyay probablehydrochlorothiazideinducedmyopericarditisfirstcasereported AT pallavibellamkonda probablehydrochlorothiazideinducedmyopericarditisfirstcasereported AT aryannmooss probablehydrochlorothiazideinducedmyopericarditisfirstcasereported |