A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions
Obsessive-compulsive disorder (OCD) is a prevalent mental condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions), significantly disrupting daily functioning and social interactions. Transcranial direct current stimulation (tDCS) presents a promisi...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-10-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556524001979 |
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| author | Ismail A. Ibrahim Ahmed Hosney Nada Nada Khalid Asar Rand Ibrahim Rawan Ahmed Farouk Almonzer Al-Qiami Sarah A. Nada Parisa Alizadeh Oghyanous Seyed Ali Noorbakhsh |
| author_facet | Ismail A. Ibrahim Ahmed Hosney Nada Nada Khalid Asar Rand Ibrahim Rawan Ahmed Farouk Almonzer Al-Qiami Sarah A. Nada Parisa Alizadeh Oghyanous Seyed Ali Noorbakhsh |
| author_sort | Ismail A. Ibrahim |
| collection | DOAJ |
| description | Obsessive-compulsive disorder (OCD) is a prevalent mental condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions), significantly disrupting daily functioning and social interactions. Transcranial direct current stimulation (tDCS) presents a promising non-invasive treatment modality aimed at alleviating symptoms. However, the evidence regarding its effectiveness remains inconclusive. This study seeks to address this gap by conducting a systematic review and meta-analysis of clinical trials, offering improved guidance for clinical intervention. A comprehensive search strategy was implemented across multiple databases, including PubMed, Cochrane CENTRAL, Embase, Scopus, and Web of Science. This search focused strictly on randomized controlled trials (RCTs) involving 147 patients. These trials evaluated the efficacy of tDCS in OCD patients. Subsequent data extraction, risk of bias assessment, and statistical analysis using Review Manager software revealed the potential efficacy of tDCS in reducing OCD symptoms. The meta-analysis not only fails to demonstrate significant superiority of active tDCS over sham tDCS but also suggests that sham tDCS may be more effective than active tDCS in reducing OCD symptoms. This finding diminishes the promise of tDCS as an effective treatment for OCD. Larger trials are warranted to further elucidate these findings. |
| format | Article |
| id | doaj-art-08da633a4ba046fca05631dfc037687a |
| institution | OA Journals |
| issn | 1873-6815 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-08da633a4ba046fca05631dfc037687a2025-08-20T01:55:21ZengElsevierExperimental Gerontology1873-68152024-10-0119611255110.1016/j.exger.2024.112551A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventionsIsmail A. Ibrahim0Ahmed Hosney Nada1Nada Khalid Asar2Rand Ibrahim3Rawan Ahmed Farouk4Almonzer Al-Qiami5Sarah A. Nada6Parisa Alizadeh Oghyanous7Seyed Ali Noorbakhsh8Faculty of Health Sciences, Fenerbahce University, Istanbul, TurkeyFaculty of Medicine, Benha University, EgyptFaculty of Medicine, Mansoura University, EgyptFaculty of Medicine, University of Aleppo, SyriaFaculty of Medicine, Al Fayoum University, EgyptFaculty of Medicine and Health Sciences, Kassala University, Kassala, SudanFaculty of Medicine, Menoufia University, EgyptIslamic Azad University, Tehran South Branch, Tehran, IranSciencebeam Institute, Istanbul, Turkey; Corresponding author.Obsessive-compulsive disorder (OCD) is a prevalent mental condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions), significantly disrupting daily functioning and social interactions. Transcranial direct current stimulation (tDCS) presents a promising non-invasive treatment modality aimed at alleviating symptoms. However, the evidence regarding its effectiveness remains inconclusive. This study seeks to address this gap by conducting a systematic review and meta-analysis of clinical trials, offering improved guidance for clinical intervention. A comprehensive search strategy was implemented across multiple databases, including PubMed, Cochrane CENTRAL, Embase, Scopus, and Web of Science. This search focused strictly on randomized controlled trials (RCTs) involving 147 patients. These trials evaluated the efficacy of tDCS in OCD patients. Subsequent data extraction, risk of bias assessment, and statistical analysis using Review Manager software revealed the potential efficacy of tDCS in reducing OCD symptoms. The meta-analysis not only fails to demonstrate significant superiority of active tDCS over sham tDCS but also suggests that sham tDCS may be more effective than active tDCS in reducing OCD symptoms. This finding diminishes the promise of tDCS as an effective treatment for OCD. Larger trials are warranted to further elucidate these findings.http://www.sciencedirect.com/science/article/pii/S0531556524001979TDCsObsessive-compulsive disorderNon-pharmacological approachTranscranial direct current stimulationY-BOCSNeuromodulation |
| spellingShingle | Ismail A. Ibrahim Ahmed Hosney Nada Nada Khalid Asar Rand Ibrahim Rawan Ahmed Farouk Almonzer Al-Qiami Sarah A. Nada Parisa Alizadeh Oghyanous Seyed Ali Noorbakhsh A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions Experimental Gerontology TDCs Obsessive-compulsive disorder Non-pharmacological approach Transcranial direct current stimulation Y-BOCS Neuromodulation |
| title | A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions |
| title_full | A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions |
| title_fullStr | A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions |
| title_full_unstemmed | A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions |
| title_short | A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions |
| title_sort | systematic review and meta analysis for the efficacy of transcranial direct current stimulation tdcs in ocd treatment a non pharmacological approach to clinical interventions |
| topic | TDCs Obsessive-compulsive disorder Non-pharmacological approach Transcranial direct current stimulation Y-BOCS Neuromodulation |
| url | http://www.sciencedirect.com/science/article/pii/S0531556524001979 |
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