Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management
Background. Acute promyelocytic leukemia is characterized by t(15;17). This leads to the formation of PML/RARα which blocks the differentiation of blasts at the stage of promyelocytes. This is reversed by all-trans-retinoic acid (ATRA), a vitamin A derivative. Acute myocardial ischemia is a rare sid...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/2829142 |
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| author | K. Govind Babu K. N. Lokesh M. C. Suresh Babu Gita R. Bhat |
| author_facet | K. Govind Babu K. N. Lokesh M. C. Suresh Babu Gita R. Bhat |
| author_sort | K. Govind Babu |
| collection | DOAJ |
| description | Background. Acute promyelocytic leukemia is characterized by t(15;17). This leads to the formation of PML/RARα which blocks the differentiation of blasts at the stage of promyelocytes. This is reversed by all-trans-retinoic acid (ATRA), a vitamin A derivative. Acute myocardial ischemia is a rare side effect of ATRA. Case Report. We report a case of acute coronary syndrome manifesting as an adverse effect of ATRA in a lady with APL who had no other risk factors for cardiovascular disease. Conclusions. We emphasize the need for high index of suspicion for the diagnosis of this entity. In the light of this case, the rare instances of ATRA associated acute myocardial ischemia recorded in the literature and the options available for treatment of acute promyelocytic leukemia sans ATRA have been reviewed. |
| format | Article |
| id | doaj-art-08d4874b0ed64210ae0ef750a30ea34e |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-08d4874b0ed64210ae0ef750a30ea34e2025-08-20T03:55:32ZengWileyCase Reports in Oncological Medicine2090-67062090-67142016-01-01201610.1155/2016/28291422829142Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on ManagementK. Govind Babu0K. N. Lokesh1M. C. Suresh Babu2Gita R. Bhat3Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Dr. M. H. Marigowda Road, Hombegowda Nagar, Bengaluru, Karnataka 560030, IndiaDepartment of Medical Oncology, Kidwai Memorial Institute of Oncology, Dr. M. H. Marigowda Road, Hombegowda Nagar, Bengaluru, Karnataka 560030, IndiaDepartment of Medical Oncology, Kidwai Memorial Institute of Oncology, Dr. M. H. Marigowda Road, Hombegowda Nagar, Bengaluru, Karnataka 560030, IndiaDepartment of Medical Oncology, Kidwai Memorial Institute of Oncology, Dr. M. H. Marigowda Road, Hombegowda Nagar, Bengaluru, Karnataka 560030, IndiaBackground. Acute promyelocytic leukemia is characterized by t(15;17). This leads to the formation of PML/RARα which blocks the differentiation of blasts at the stage of promyelocytes. This is reversed by all-trans-retinoic acid (ATRA), a vitamin A derivative. Acute myocardial ischemia is a rare side effect of ATRA. Case Report. We report a case of acute coronary syndrome manifesting as an adverse effect of ATRA in a lady with APL who had no other risk factors for cardiovascular disease. Conclusions. We emphasize the need for high index of suspicion for the diagnosis of this entity. In the light of this case, the rare instances of ATRA associated acute myocardial ischemia recorded in the literature and the options available for treatment of acute promyelocytic leukemia sans ATRA have been reviewed.http://dx.doi.org/10.1155/2016/2829142 |
| spellingShingle | K. Govind Babu K. N. Lokesh M. C. Suresh Babu Gita R. Bhat Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management Case Reports in Oncological Medicine |
| title | Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management |
| title_full | Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management |
| title_fullStr | Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management |
| title_full_unstemmed | Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management |
| title_short | Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management |
| title_sort | acute coronary syndrome manifesting as an adverse effect of all trans retinoic acid in acute promyelocytic leukemia a case report with review of the literature and a spotlight on management |
| url | http://dx.doi.org/10.1155/2016/2829142 |
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