Renal Impact of a High-Loading Dose of Amikacin in Critically Ill Patients

Renal Impact of a High-Loading Dose of Amikacin in Critically Ill Patients

Background: Aminoglycosides are potent bactericidal antibiotics primarily employed for gram-negative infections. However, they face limitations due to potential renal toxicity when administered at high doses. This study aimed to assess the nephrotoxicity of amikacin (AMK) at two distinct dosage leve...

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Bibliographic Details
Main Authors: Laleh Mahmoudi, Arezoo Ahmadi, Motahareh Mahi-Birjand, Effat Alemzadeh, Parvin Askari, Ramin Niknam, Mojtaba Mojtahedzadeh
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2025-07-01
Series:Pharmaceutical Sciences
Subjects:
amikacin
acute kidney injury
critically ill patients
nephrotoxicity
renal biomarkers
il-18
Online Access:https://ps.tbzmed.ac.ir/PDF/ps-31-330.pdf
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