SARS-CoV-2 infection of salivary glands compromises the production of a secreted antifungal peptide with potential implications for development of oral candidiasis.

SARS-CoV-2 infection of salivary glands compromises the production of a secreted antifungal peptide with potential implications for development of oral candidiasis.

Saliva contains antimicrobial peptides considered integral components of host innate immunity, and crucial for protection against colonizing microbial species. Most notable is histatin-5 which is exclusively produced in salivary glands with uniquely potent antifungal activity against the opportunist...

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Bibliographic Details
Main Authors: Areej A Alfaifi, Tristan W Wang, Paola Perez, Ahmed S Sultan, Timothy F Meiller, Peter Rock, David E Kleiner, Daniel S Chertow, Stephen M Hewitt, Billel Gasmi, Sydney Stein, Sabrina Ramelli, Daniel Martin, Blake M Warner, Mary Ann Jabra-Rizk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012375
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