The Influence of Cycloferone on the Effectiveness of Pharmacotherapy of Wide Spectrum of Infectious Diseases in Children and Adults: Systematic Review and Meta-Analysis
The object of research was an array of data on the clinical effectiveness of Cycloferon tablets and injections for intestinal infections, sepsis, meningitis,and brucellosis in children and adults, extracted from publications in peer-reviewed scientific journals. The aim of the work was to evaluate t...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/107 |
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| author | N. K. Mazina P. V. Mazin D. V. Redkina |
| author_facet | N. K. Mazina P. V. Mazin D. V. Redkina |
| author_sort | N. K. Mazina |
| collection | DOAJ |
| description | The object of research was an array of data on the clinical effectiveness of Cycloferon tablets and injections for intestinal infections, sepsis, meningitis,and brucellosis in children and adults, extracted from publications in peer-reviewed scientific journals. The aim of the work was to evaluate the clinical effectiveness of Cycloferon by comparing the results (outcomes) of its use against the background of basic therapy of acute and chronic infectious diseases of bacterial and viral genesis with different localization, taking into account the heterogeneity of the comparison groups and high variability of the indicator parameters of the response to the drug. Formalized parameters of clinical effectiveness of Cycloferon and background therapy, such as OR, the increase in absolute and relative benefits, NNT, were compared. High variability of indicators was leveled by the symmetry of the comparison groups. Combining the comparison groups in the meta-analysis process increased the statistical power of the study and allowed giving a generalized assessment of the clinical efficacy of the drug. It is shown that the use of cycloferon for the treatment and prevention of infectious diseases in adults and children more than doubles the chances of recovery and diminishes the recurrence of infectious diseases. |
| format | Article |
| id | doaj-art-08c4e774e5ea4981941cbceb38da8a48 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-08c4e774e5ea4981941cbceb38da8a482025-08-20T03:20:37ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-016311-123140106The Influence of Cycloferone on the Effectiveness of Pharmacotherapy of Wide Spectrum of Infectious Diseases in Children and Adults: Systematic Review and Meta-AnalysisN. K. Mazina0P. V. Mazin1D. V. Redkina2Kirov State Medical UniversityKirov State Medical UniversityKirov State Medical UniversityThe object of research was an array of data on the clinical effectiveness of Cycloferon tablets and injections for intestinal infections, sepsis, meningitis,and brucellosis in children and adults, extracted from publications in peer-reviewed scientific journals. The aim of the work was to evaluate the clinical effectiveness of Cycloferon by comparing the results (outcomes) of its use against the background of basic therapy of acute and chronic infectious diseases of bacterial and viral genesis with different localization, taking into account the heterogeneity of the comparison groups and high variability of the indicator parameters of the response to the drug. Formalized parameters of clinical effectiveness of Cycloferon and background therapy, such as OR, the increase in absolute and relative benefits, NNT, were compared. High variability of indicators was leveled by the symmetry of the comparison groups. Combining the comparison groups in the meta-analysis process increased the statistical power of the study and allowed giving a generalized assessment of the clinical efficacy of the drug. It is shown that the use of cycloferon for the treatment and prevention of infectious diseases in adults and children more than doubles the chances of recovery and diminishes the recurrence of infectious diseases.https://www.antibiotics-chemotherapy.ru/jour/article/view/107cycloferongastrointestinal infectionschronic brucellosismeningitissepsisunified indicators of clinical effectivenessfrequency parametersmeta-analysisodds ratio |
| spellingShingle | N. K. Mazina P. V. Mazin D. V. Redkina The Influence of Cycloferone on the Effectiveness of Pharmacotherapy of Wide Spectrum of Infectious Diseases in Children and Adults: Systematic Review and Meta-Analysis Антибиотики и Химиотерапия cycloferon gastrointestinal infections chronic brucellosis meningitis sepsis unified indicators of clinical effectiveness frequency parameters meta-analysis odds ratio |
| title | The Influence of Cycloferone on the Effectiveness of Pharmacotherapy of Wide Spectrum of Infectious Diseases in Children and Adults: Systematic Review and Meta-Analysis |
| title_full | The Influence of Cycloferone on the Effectiveness of Pharmacotherapy of Wide Spectrum of Infectious Diseases in Children and Adults: Systematic Review and Meta-Analysis |
| title_fullStr | The Influence of Cycloferone on the Effectiveness of Pharmacotherapy of Wide Spectrum of Infectious Diseases in Children and Adults: Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Influence of Cycloferone on the Effectiveness of Pharmacotherapy of Wide Spectrum of Infectious Diseases in Children and Adults: Systematic Review and Meta-Analysis |
| title_short | The Influence of Cycloferone on the Effectiveness of Pharmacotherapy of Wide Spectrum of Infectious Diseases in Children and Adults: Systematic Review and Meta-Analysis |
| title_sort | influence of cycloferone on the effectiveness of pharmacotherapy of wide spectrum of infectious diseases in children and adults systematic review and meta analysis |
| topic | cycloferon gastrointestinal infections chronic brucellosis meningitis sepsis unified indicators of clinical effectiveness frequency parameters meta-analysis odds ratio |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/107 |
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