Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.
KCa3.1 (also known as SK4 or IK1) is a mammalian intermediate-conductance potassium channel that plays a critical role in the activation of T cells, B cells, and mast cells, effluxing potassium ions to maintain a negative membrane potential for influxing calcium ions. KCa3.1 shares primary sequence...
Saved in:
| Main Authors: | Tianyang Ji, Senena Corbalán-García, Stevan R Hubbard |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199942&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis.
by: Katy M Roach, et al.
Published: (2013-01-01) -
Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice
by: O. Daniel Vera, et al.
Published: (2025-02-01) -
Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation
by: Edda S. F. Matthees, et al.
Published: (2025-07-01) -
Genetic silencing of KCa3.1 inhibits atherosclerosis in ApoE null mice
by: P. Alam, et al.
Published: (2025-12-01) -
Increased Levels of ER Stress and Apoptosis in a Sheep Model for Pulmonary Fibrosis Are Alleviated by In Vivo Blockade of the KCa3.1 Ion Channel
by: Udari E. Perera, et al.
Published: (2021-01-01)