Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers
Abstract Sideroflexin (SFXN) family genes encode for a group of mitochondrial proteins involved in cellular processes such as iron homeostasis, amino acid metabolism, and energy production. Recent studies showed that they were aberrantly expressed in certain human cancers. However, there is a paucit...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Human Genomics |
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| Online Access: | https://doi.org/10.1186/s40246-024-00705-6 |
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| author | Hua Huang Huibo Lian Wang Liu Benyi Li Runzhi Zhu Haiyan Shao |
| author_facet | Hua Huang Huibo Lian Wang Liu Benyi Li Runzhi Zhu Haiyan Shao |
| author_sort | Hua Huang |
| collection | DOAJ |
| description | Abstract Sideroflexin (SFXN) family genes encode for a group of mitochondrial proteins involved in cellular processes such as iron homeostasis, amino acid metabolism, and energy production. Recent studies showed that they were aberrantly expressed in certain human cancers. However, there is a paucity of information about their expression in prostate cancer. In this study, we took a comprehensive approach to investigate their expression profiles in benign prostate tissue, prostate-derived cell lines, and prostate cancer tissues using multiple transcriptome datasets. Our results showed that SFXN1/3/4 genes were predominantly expressed in prostate tissue and cell lines. SFXN2/4 genes were significantly upregulated while the SFXN3 expression was significantly downregulated in malignant tissues compared to benign tissues. SFXN4 expression was identified as a diagnostic biomarker and prognostic factor for unfavorite survival outcomes. In advanced prostate cancers, SFXN2/4 expressions were positively correlated with the androgen receptor signaling activity but negatively correlated with the neuroendocrinal features. Further analysis discovered that SFXN5 expression was significantly elevated in neuroendocrinal prostate cancers. In conclusion, SFXN2/4 expressions are novel biomarkers in prostate cancer diagnosis and prognosis. |
| format | Article |
| id | doaj-art-08b75fa946ec41e1aa0af0f625c2c30c |
| institution | Kabale University |
| issn | 1479-7364 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj-art-08b75fa946ec41e1aa0af0f625c2c30c2025-02-09T12:46:35ZengBMCHuman Genomics1479-73642025-02-0119111310.1186/s40246-024-00705-6Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancersHua Huang0Huibo Lian1Wang Liu2Benyi Li3Runzhi Zhu4Haiyan Shao5Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital, The Affiliated People’s Hospital, Hangzhou Medical CollegeUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital, The Affiliated People’s Hospital, Hangzhou Medical CollegeDepartment of Urology, The University of Kansas Medical CenterDepartment of Urology, The University of Kansas Medical CenterThe Children’s Hospital, Zhejiang University School of MedicineUrology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital, The Affiliated People’s Hospital, Hangzhou Medical CollegeAbstract Sideroflexin (SFXN) family genes encode for a group of mitochondrial proteins involved in cellular processes such as iron homeostasis, amino acid metabolism, and energy production. Recent studies showed that they were aberrantly expressed in certain human cancers. However, there is a paucity of information about their expression in prostate cancer. In this study, we took a comprehensive approach to investigate their expression profiles in benign prostate tissue, prostate-derived cell lines, and prostate cancer tissues using multiple transcriptome datasets. Our results showed that SFXN1/3/4 genes were predominantly expressed in prostate tissue and cell lines. SFXN2/4 genes were significantly upregulated while the SFXN3 expression was significantly downregulated in malignant tissues compared to benign tissues. SFXN4 expression was identified as a diagnostic biomarker and prognostic factor for unfavorite survival outcomes. In advanced prostate cancers, SFXN2/4 expressions were positively correlated with the androgen receptor signaling activity but negatively correlated with the neuroendocrinal features. Further analysis discovered that SFXN5 expression was significantly elevated in neuroendocrinal prostate cancers. In conclusion, SFXN2/4 expressions are novel biomarkers in prostate cancer diagnosis and prognosis.https://doi.org/10.1186/s40246-024-00705-6Prostate cancerSideroflexin family genesCastration-resistanceNeuroendocrinal progressionAndrogen receptor modulation |
| spellingShingle | Hua Huang Huibo Lian Wang Liu Benyi Li Runzhi Zhu Haiyan Shao Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers Human Genomics Prostate cancer Sideroflexin family genes Castration-resistance Neuroendocrinal progression Androgen receptor modulation |
| title | Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers |
| title_full | Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers |
| title_fullStr | Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers |
| title_full_unstemmed | Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers |
| title_short | Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers |
| title_sort | sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers |
| topic | Prostate cancer Sideroflexin family genes Castration-resistance Neuroendocrinal progression Androgen receptor modulation |
| url | https://doi.org/10.1186/s40246-024-00705-6 |
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