CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study
Background: Breast cancer is the leading cause of death for women worldwide. Optimal methods for most cancer control require the use of appropriate biomarkers. Recently, circular RNAs (circRNAs), as closed-loop RNA molecules generated through reverse splicing, have emerged as promising biomarkers f...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2024-10-01
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| Series: | Basic & Clinical Cancer Research |
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| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/544 |
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| author | Saba Mirzaei Mahdieh Salimi Hossein Mozdarani |
| author_facet | Saba Mirzaei Mahdieh Salimi Hossein Mozdarani |
| author_sort | Saba Mirzaei |
| collection | DOAJ |
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Background: Breast cancer is the leading cause of death for women worldwide. Optimal methods for most cancer control require the use of appropriate biomarkers. Recently, circular RNAs (circRNAs), as closed-loop RNA molecules generated through reverse splicing, have emerged as promising biomarkers for cancer development.
Methods: In this observation, the expression of 3 unique circRNAs - cdr1as, circRNA-000284, circ-ITCH - within the peripheral blood of breast cancer patients was studied using Real-Time RT-PCR before and after chemotherapy compared with the control.
Results: The data confirmed that the analyzed circRNAs expression was significantly altered in breast cancer patients compared to the controls. These alterations have been related to advanced stages, lymph node involvement, and metastasis. CircRNA-000284 expression considerably decreased after chemotherapy. This may proposed its potential as a biomarker for monitoring treatment response.
Conclusion: These findings provide valuable insights for the development of novel
strategies in the management and treatment of breast cancer. However, further studies are required to validate the clinical utility of these circRNAs as biomarkers and to explore their underlying mechanisms in breast cancer progression.
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| format | Article |
| id | doaj-art-08b6b8335ad946469dc5599eff68d77d |
| institution | Kabale University |
| issn | 2228-6527 2228-5466 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Basic & Clinical Cancer Research |
| spelling | doaj-art-08b6b8335ad946469dc5599eff68d77d2025-02-09T08:54:19ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662024-10-01154CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive StudySaba Mirzaei0Mahdieh Salimi1Hossein Mozdarani2Department of Medical Genetics, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, IranNational Institute of Genetic Engineering and Biotechnology (NIGEB)Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Background: Breast cancer is the leading cause of death for women worldwide. Optimal methods for most cancer control require the use of appropriate biomarkers. Recently, circular RNAs (circRNAs), as closed-loop RNA molecules generated through reverse splicing, have emerged as promising biomarkers for cancer development. Methods: In this observation, the expression of 3 unique circRNAs - cdr1as, circRNA-000284, circ-ITCH - within the peripheral blood of breast cancer patients was studied using Real-Time RT-PCR before and after chemotherapy compared with the control. Results: The data confirmed that the analyzed circRNAs expression was significantly altered in breast cancer patients compared to the controls. These alterations have been related to advanced stages, lymph node involvement, and metastasis. CircRNA-000284 expression considerably decreased after chemotherapy. This may proposed its potential as a biomarker for monitoring treatment response. Conclusion: These findings provide valuable insights for the development of novel strategies in the management and treatment of breast cancer. However, further studies are required to validate the clinical utility of these circRNAs as biomarkers and to explore their underlying mechanisms in breast cancer progression. https://bccr.tums.ac.ir/index.php/bccrj/article/view/544Breast cancercircRNAsBiomarkersChemotherapyPrognosis |
| spellingShingle | Saba Mirzaei Mahdieh Salimi Hossein Mozdarani CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study Basic & Clinical Cancer Research Breast cancer circRNAs Biomarkers Chemotherapy Prognosis |
| title | CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study |
| title_full | CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study |
| title_fullStr | CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study |
| title_full_unstemmed | CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study |
| title_short | CircRNAs as Possible Potential Biomarkers for Breast Cancer Prognosis and Chemotherapy Response: A Comprehensive Study |
| title_sort | circrnas as possible potential biomarkers for breast cancer prognosis and chemotherapy response a comprehensive study |
| topic | Breast cancer circRNAs Biomarkers Chemotherapy Prognosis |
| url | https://bccr.tums.ac.ir/index.php/bccrj/article/view/544 |
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