Analysis of surgical and therapeutic interventions in patients with craniopharyngioma undergoing open transcranial resections versus endoscopic endonasal resections: A systematic review
Craniopharyngiomas (CPMs) are uncommon embryonic anomalies located in the sellar and parasellar regions, characterized by their exceedingly low histological grade (WHO I). The incidence of 1-3 new cases per million each year globally. The aim of this systematic review is to conduct a comparative ana...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Annals of Oncology Research and Therapy |
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| Online Access: | https://journals.lww.com/10.4103/aort.aort_49_24 |
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| author | Daniel Encarnacion-Santos Ismail Bozkurt Gennady Chmutin Egor Chmutin Murat Pashev Bipin Chaurasia Nazmin Ahmed Emmanuel Batista-Geraldino Baraniko Eromanga |
| author_facet | Daniel Encarnacion-Santos Ismail Bozkurt Gennady Chmutin Egor Chmutin Murat Pashev Bipin Chaurasia Nazmin Ahmed Emmanuel Batista-Geraldino Baraniko Eromanga |
| author_sort | Daniel Encarnacion-Santos |
| collection | DOAJ |
| description | Craniopharyngiomas (CPMs) are uncommon embryonic anomalies located in the sellar and parasellar regions, characterized by their exceedingly low histological grade (WHO I). The incidence of 1-3 new cases per million each year globally. The aim of this systematic review is to conduct a comparative analysis of EEN and TC therapies, irrespective of the total number of patients who received alternative interventions. Two primary subtypes of CPMs have been recognized: papillary, predominantly observed in adults, and adamantinomatous, primarily found in children and resembling neoplasms that generate enamel-like structures in the oropharynx. Adults with the adamantinomatous variant are associated with mutations in the β-catenin gene, a key mediator of the Wnt CTNNB1 pathway, while adults with the BRAF V600E mutation are frequently associated with the papillary subtype. Materials and Methods: Following that, the scientific literature is examined using the Preferred Reporting Items for Systematic Reviews (PRISMA) Direct and PubMed/MEDLINE through January-August 2024. The IBM SPSS Statistics for Windows, Version 26.0 (released 2020; IBM Corp., Armonk, New York, United States) and EXCEL criteria were used for the statistical study. Results: This comprehensive analysis includes 3076 patients with craniopharyngiomas. Among these, 1339 patients had endoscopic endonasal resections, whereas 591 patients underwent open transcranial resections. For this form of pathology, endoscopic resection was the more favorable alternative. Conclusion: We discovered that craniopharyngiomas Because total eradication is not achieved, recurrences are common, therefore elimination by new intervention, plus adjuvant radiation or chemotherapy, plus surgery. |
| format | Article |
| id | doaj-art-08b25e84bd0d498c8e41b6ae4778ec1e |
| institution | Kabale University |
| issn | 2772-8382 2772-8390 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Oncology Research and Therapy |
| spelling | doaj-art-08b25e84bd0d498c8e41b6ae4778ec1e2025-08-20T03:29:26ZengWolters Kluwer Medknow PublicationsAnnals of Oncology Research and Therapy2772-83822772-83902025-07-015210311310.4103/aort.aort_49_24Analysis of surgical and therapeutic interventions in patients with craniopharyngioma undergoing open transcranial resections versus endoscopic endonasal resections: A systematic reviewDaniel Encarnacion-SantosIsmail BozkurtGennady ChmutinEgor ChmutinMurat PashevBipin ChaurasiaNazmin AhmedEmmanuel Batista-GeraldinoBaraniko EromangaCraniopharyngiomas (CPMs) are uncommon embryonic anomalies located in the sellar and parasellar regions, characterized by their exceedingly low histological grade (WHO I). The incidence of 1-3 new cases per million each year globally. The aim of this systematic review is to conduct a comparative analysis of EEN and TC therapies, irrespective of the total number of patients who received alternative interventions. Two primary subtypes of CPMs have been recognized: papillary, predominantly observed in adults, and adamantinomatous, primarily found in children and resembling neoplasms that generate enamel-like structures in the oropharynx. Adults with the adamantinomatous variant are associated with mutations in the β-catenin gene, a key mediator of the Wnt CTNNB1 pathway, while adults with the BRAF V600E mutation are frequently associated with the papillary subtype. Materials and Methods: Following that, the scientific literature is examined using the Preferred Reporting Items for Systematic Reviews (PRISMA) Direct and PubMed/MEDLINE through January-August 2024. The IBM SPSS Statistics for Windows, Version 26.0 (released 2020; IBM Corp., Armonk, New York, United States) and EXCEL criteria were used for the statistical study. Results: This comprehensive analysis includes 3076 patients with craniopharyngiomas. Among these, 1339 patients had endoscopic endonasal resections, whereas 591 patients underwent open transcranial resections. For this form of pathology, endoscopic resection was the more favorable alternative. Conclusion: We discovered that craniopharyngiomas Because total eradication is not achieved, recurrences are common, therefore elimination by new intervention, plus adjuvant radiation or chemotherapy, plus surgery.https://journals.lww.com/10.4103/aort.aort_49_24craniopharyngiomaendoscopic endonasalinterventionopen transcranial resectionoutcomessurgical resectiontreatment |
| spellingShingle | Daniel Encarnacion-Santos Ismail Bozkurt Gennady Chmutin Egor Chmutin Murat Pashev Bipin Chaurasia Nazmin Ahmed Emmanuel Batista-Geraldino Baraniko Eromanga Analysis of surgical and therapeutic interventions in patients with craniopharyngioma undergoing open transcranial resections versus endoscopic endonasal resections: A systematic review Annals of Oncology Research and Therapy craniopharyngioma endoscopic endonasal intervention open transcranial resection outcomes surgical resection treatment |
| title | Analysis of surgical and therapeutic interventions in patients with craniopharyngioma undergoing open transcranial resections versus endoscopic endonasal resections: A systematic review |
| title_full | Analysis of surgical and therapeutic interventions in patients with craniopharyngioma undergoing open transcranial resections versus endoscopic endonasal resections: A systematic review |
| title_fullStr | Analysis of surgical and therapeutic interventions in patients with craniopharyngioma undergoing open transcranial resections versus endoscopic endonasal resections: A systematic review |
| title_full_unstemmed | Analysis of surgical and therapeutic interventions in patients with craniopharyngioma undergoing open transcranial resections versus endoscopic endonasal resections: A systematic review |
| title_short | Analysis of surgical and therapeutic interventions in patients with craniopharyngioma undergoing open transcranial resections versus endoscopic endonasal resections: A systematic review |
| title_sort | analysis of surgical and therapeutic interventions in patients with craniopharyngioma undergoing open transcranial resections versus endoscopic endonasal resections a systematic review |
| topic | craniopharyngioma endoscopic endonasal intervention open transcranial resection outcomes surgical resection treatment |
| url | https://journals.lww.com/10.4103/aort.aort_49_24 |
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