Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients
Abstract Background Rheumatoid arthritis (RA) is a long-term autoimmune disease causing chronic progressive inflammatory disease. In this study, we aimed to evaluate a new strategy for gene polymorphism of IL17A which may be related to the risk of rheumatoid arthritis in Iranian patients. Methods We...
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SpringerOpen
2025-07-01
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| Series: | Egyptian Journal of Medical Human Genetics |
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| Online Access: | https://doi.org/10.1186/s43042-025-00757-w |
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| author | Mozhgan Khojasteh Reza Mansori Ali Dehghani Mehdi Mahmoudi Saed Mazazarzadeh Emad Babakhanzadeh |
| author_facet | Mozhgan Khojasteh Reza Mansori Ali Dehghani Mehdi Mahmoudi Saed Mazazarzadeh Emad Babakhanzadeh |
| author_sort | Mozhgan Khojasteh |
| collection | DOAJ |
| description | Abstract Background Rheumatoid arthritis (RA) is a long-term autoimmune disease causing chronic progressive inflammatory disease. In this study, we aimed to evaluate a new strategy for gene polymorphism of IL17A which may be related to the risk of rheumatoid arthritis in Iranian patients. Methods We examined the genes IL17A and IL17F in relation to RA. They compared the DNA of 100 RA patients and 92 healthy individuals for the IL17A gene, and 116 RA patients and 107 healthy individuals for the IL17F gene. A technique called PCR–RFLP was used to analyze their genetic makeup. SPSS software was used for statistical analyses. Results There was a significant association between the patients and control group in rs2275913 (OR = 2.97, 95%CI = 1.38–6.46, P = < 0.001). However, there was no significant relationship between the patient and control group at rs763780 (OR = 1.49, 95%CI = 0.806–2.76, P = 0.201). Also, in this study, the association between genotypes mentioned above and Anti-ccp was investigated. There was no significant correlation between any genotype and positive Anti-ccp. (P = 0.142 for rs2275913 and P = 0.330 for rs763780). Conclusion Based on this study, rs2275913 polymorphism of gene IL17A could contribute to the risk of rheumatoid arthritis in Iranian patients. |
| format | Article |
| id | doaj-art-08ae3c25a2c245008dee4ba2646bd265 |
| institution | DOAJ |
| issn | 2090-2441 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj-art-08ae3c25a2c245008dee4ba2646bd2652025-08-20T03:05:13ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412025-07-012611610.1186/s43042-025-00757-wAssociation of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patientsMozhgan Khojasteh0Reza Mansori1Ali Dehghani2Mehdi Mahmoudi3Saed Mazazarzadeh4Emad Babakhanzadeh5Department of Clinical Immunology, International Campus, Shahid Sadoughi University of Medical SciencesDepartment of Clinical Immunology, International Campus, Shahid Sadoughi University of Medical SciencesDepartment of Rheumatology, Shahid Sadoughi University of Medical SciencesRheumatology Research Center, Tehran University of Medical SciencesDepartment of Clinical Immunology, International Campus, Shahid Sadoughi University of Medical SciencesDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesAbstract Background Rheumatoid arthritis (RA) is a long-term autoimmune disease causing chronic progressive inflammatory disease. In this study, we aimed to evaluate a new strategy for gene polymorphism of IL17A which may be related to the risk of rheumatoid arthritis in Iranian patients. Methods We examined the genes IL17A and IL17F in relation to RA. They compared the DNA of 100 RA patients and 92 healthy individuals for the IL17A gene, and 116 RA patients and 107 healthy individuals for the IL17F gene. A technique called PCR–RFLP was used to analyze their genetic makeup. SPSS software was used for statistical analyses. Results There was a significant association between the patients and control group in rs2275913 (OR = 2.97, 95%CI = 1.38–6.46, P = < 0.001). However, there was no significant relationship between the patient and control group at rs763780 (OR = 1.49, 95%CI = 0.806–2.76, P = 0.201). Also, in this study, the association between genotypes mentioned above and Anti-ccp was investigated. There was no significant correlation between any genotype and positive Anti-ccp. (P = 0.142 for rs2275913 and P = 0.330 for rs763780). Conclusion Based on this study, rs2275913 polymorphism of gene IL17A could contribute to the risk of rheumatoid arthritis in Iranian patients.https://doi.org/10.1186/s43042-025-00757-wRheumatoid ArthritisIL17Single-nucleotide polymorphismAnti-CCP |
| spellingShingle | Mozhgan Khojasteh Reza Mansori Ali Dehghani Mehdi Mahmoudi Saed Mazazarzadeh Emad Babakhanzadeh Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients Egyptian Journal of Medical Human Genetics Rheumatoid Arthritis IL17 Single-nucleotide polymorphism Anti-CCP |
| title | Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients |
| title_full | Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients |
| title_fullStr | Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients |
| title_full_unstemmed | Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients |
| title_short | Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients |
| title_sort | association of il 17a gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in iranian patients |
| topic | Rheumatoid Arthritis IL17 Single-nucleotide polymorphism Anti-CCP |
| url | https://doi.org/10.1186/s43042-025-00757-w |
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