Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients

Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients

Abstract Background Rheumatoid arthritis (RA) is a long-term autoimmune disease causing chronic progressive inflammatory disease. In this study, we aimed to evaluate a new strategy for gene polymorphism of IL17A which may be related to the risk of rheumatoid arthritis in Iranian patients. Methods We...

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Bibliographic Details
Main Authors: Mozhgan Khojasteh, Reza Mansori, Ali Dehghani, Mehdi Mahmoudi, Saed Mazazarzadeh, Emad Babakhanzadeh
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Rheumatoid Arthritis
IL17
Single-nucleotide polymorphism
Anti-CCP
Online Access:https://doi.org/10.1186/s43042-025-00757-w
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Summary:Abstract Background Rheumatoid arthritis (RA) is a long-term autoimmune disease causing chronic progressive inflammatory disease. In this study, we aimed to evaluate a new strategy for gene polymorphism of IL17A which may be related to the risk of rheumatoid arthritis in Iranian patients. Methods We examined the genes IL17A and IL17F in relation to RA. They compared the DNA of 100 RA patients and 92 healthy individuals for the IL17A gene, and 116 RA patients and 107 healthy individuals for the IL17F gene. A technique called PCR–RFLP was used to analyze their genetic makeup. SPSS software was used for statistical analyses. Results There was a significant association between the patients and control group in rs2275913 (OR = 2.97, 95%CI = 1.38–6.46, P =  < 0.001). However, there was no significant relationship between the patient and control group at rs763780 (OR = 1.49, 95%CI = 0.806–2.76, P = 0.201). Also, in this study, the association between genotypes mentioned above and Anti-ccp was investigated. There was no significant correlation between any genotype and positive Anti-ccp. (P = 0.142 for rs2275913 and P = 0.330 for rs763780). Conclusion Based on this study, rs2275913 polymorphism of gene IL17A could contribute to the risk of rheumatoid arthritis in Iranian patients.
ISSN:2090-2441

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