A next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability

A next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability

We previously described an in vitro single-chain fragment (scFv) library platform originally designed to generate antibodies with excellent developability properties. The platform design was based on the use of clinical antibodies as scaffolds into which replicated natural complementarity-determinin...

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Bibliographic Details
Main Authors: Fortunato Ferrara, Adeline Fanni, Andre A. R. Teixeira, Esteban Molina, Camila Leal-Lopes, Ashley DeAguero, Sara D’Angelo, M. Frank Erasmus, Laura Spector, Luis Antonio Rodriguez Carnero, Jianquan Li, Thomas J. Pohl, Nikolai Suslov, Klervi Desrumeaux, Conor McMahon, Sagar Kathuria, Andrew R. M. Bradbury
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Recombinant antibody libraries
Fab
phage display
yeast display
developability
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2394230
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