Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite Nanoparticles
Biocompatible vaterite microspheres, renowned for their porous structure, are promising carriers for magnetic nanoparticles (MNPs) in biomedical applications such as targeted drug delivery and diagnostic imaging. Precise control over the magnetic moment of individual microspheres is crucial for thes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/15/15/1141 |
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| author | Mona Jani Hani Barhum Janis Alnis Mohammad Attrash Tamara Amro Nir Bar-Gill Toms Salgals Pavel Ginzburg Ilja Fescenko |
| author_facet | Mona Jani Hani Barhum Janis Alnis Mohammad Attrash Tamara Amro Nir Bar-Gill Toms Salgals Pavel Ginzburg Ilja Fescenko |
| author_sort | Mona Jani |
| collection | DOAJ |
| description | Biocompatible vaterite microspheres, renowned for their porous structure, are promising carriers for magnetic nanoparticles (MNPs) in biomedical applications such as targeted drug delivery and diagnostic imaging. Precise control over the magnetic moment of individual microspheres is crucial for these applications. This study employs widefield quantum diamond microscopy to map the stray magnetic fields of individual vaterite microspheres (3–10 μm) loaded with Fe<sub>3</sub>O<sub>4</sub> MNPs of varying sizes (5 nm, 10 nm, and 20 nm). By analyzing over 35 microspheres under a 222 mT external magnetizing field, we measured peak-to-peak stray field amplitudes of 41 ± 1 μT for 5 nm and 10 nm superparamagnetic MNPs, reflecting their comparable magnetic response, and 12 ± 1 μT for 20 nm ferrimagnetic MNPs, due to distinct magnetization behavior. Finite-element simulations confirm variations in MNP distribution and magnetization uniformity within the vaterite matrix, with each microsphere encapsulating thousands of MNPs to generate its magnetization. This high-resolution magnetic imaging approach yields critical insights into MNP-loaded vaterite, enabling optimized synthesis and magnetically controlled systems for precision therapies and diagnostics. |
| format | Article |
| id | doaj-art-08a8775d9fe84835afc19b53ffcd2c1f |
| institution | Kabale University |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-08a8775d9fe84835afc19b53ffcd2c1f2025-08-20T03:36:22ZengMDPI AGNanomaterials2079-49912025-07-011515114110.3390/nano15151141Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite NanoparticlesMona Jani0Hani Barhum1Janis Alnis2Mohammad Attrash3Tamara Amro4Nir Bar-Gill5Toms Salgals6Pavel Ginzburg7Ilja Fescenko8Laser Center, Faculty of Science and Technology, University of Latvia, LV-1004 Riga, LatviaTriangle Regional Research and Development Center, Kfar Qara 75231, IsraelInstitute of Atomic Physics and Spectroscopy, Faculty of Science and Technology, University of Latvia, LV-1004 Riga, LatviaTriangle Regional Research and Development Center, Kfar Qara 75231, IsraelThe Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904, IsraelThe Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904, IsraelInstitute of Telecommunications, Riga Technical University, LV-1048 Riga, LatviaSchool of Electrical Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, IsraelLaser Center, Faculty of Science and Technology, University of Latvia, LV-1004 Riga, LatviaBiocompatible vaterite microspheres, renowned for their porous structure, are promising carriers for magnetic nanoparticles (MNPs) in biomedical applications such as targeted drug delivery and diagnostic imaging. Precise control over the magnetic moment of individual microspheres is crucial for these applications. This study employs widefield quantum diamond microscopy to map the stray magnetic fields of individual vaterite microspheres (3–10 μm) loaded with Fe<sub>3</sub>O<sub>4</sub> MNPs of varying sizes (5 nm, 10 nm, and 20 nm). By analyzing over 35 microspheres under a 222 mT external magnetizing field, we measured peak-to-peak stray field amplitudes of 41 ± 1 μT for 5 nm and 10 nm superparamagnetic MNPs, reflecting their comparable magnetic response, and 12 ± 1 μT for 20 nm ferrimagnetic MNPs, due to distinct magnetization behavior. Finite-element simulations confirm variations in MNP distribution and magnetization uniformity within the vaterite matrix, with each microsphere encapsulating thousands of MNPs to generate its magnetization. This high-resolution magnetic imaging approach yields critical insights into MNP-loaded vaterite, enabling optimized synthesis and magnetically controlled systems for precision therapies and diagnostics.https://www.mdpi.com/2079-4991/15/15/1141NV centersvateritemagnetic imagingquantum sensorsnanoparticles |
| spellingShingle | Mona Jani Hani Barhum Janis Alnis Mohammad Attrash Tamara Amro Nir Bar-Gill Toms Salgals Pavel Ginzburg Ilja Fescenko Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite Nanoparticles Nanomaterials NV centers vaterite magnetic imaging quantum sensors nanoparticles |
| title | Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite Nanoparticles |
| title_full | Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite Nanoparticles |
| title_fullStr | Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite Nanoparticles |
| title_full_unstemmed | Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite Nanoparticles |
| title_short | Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite Nanoparticles |
| title_sort | quantum diamond microscopy of individual vaterite microspheres containing magnetite nanoparticles |
| topic | NV centers vaterite magnetic imaging quantum sensors nanoparticles |
| url | https://www.mdpi.com/2079-4991/15/15/1141 |
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