Safety of unconventional antibody-drug conjugate L-DOS47 in a phase I/II monotherapy study targeting advanced NSCLC

Safety of unconventional antibody-drug conjugate L-DOS47 in a phase I/II monotherapy study targeting advanced NSCLC

IntroductionTumor acidity is emerging as a hallmark of cancer and carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) expression is frequently increased in acidic tumors. L-DOS47, a novel antibody-drug conjugate (ADC), consists of jack bean urease cross-linked to anti-CEACAM6 nanobod...

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Main Authors:	Rodryg Ramlau, Dariusz M. Kowalski, Aleksandra Szczęsna, Cezary Szczylik, Young Ou, Martin Köbel, Gabrielle M. Siegers, Kim J. Gaspar, Brenda Lee, Kazimierz Roszkowski-Sliz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Oncology
Subjects:	tumor microenvironment ADC nanobody-drug conjugate CEACAM6 CEACAM-6 acidosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1544967/full
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