Thymectomy immediately after myasthenic crisis
Introduction. Myasthenic crisis ( MC) refers to rapid progression of myasthenic weakness accompanied by ventilatory and bulbar dysfunction. Since there is no single standard accepted in the treatment of every patient in myasthenic crisis, we report our experience in the treatment of such a patient....
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| Format: | Article |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2021-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900139M.pdf |
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| author | Martić Vesna Marić Nebojša Đorđević Dragan |
| author_facet | Martić Vesna Marić Nebojša Đorđević Dragan |
| author_sort | Martić Vesna |
| collection | DOAJ |
| description | Introduction. Myasthenic crisis ( MC) refers to rapid progression of myasthenic weakness accompanied by ventilatory and bulbar dysfunction. Since there is no single standard accepted in the treatment of every patient in myasthenic crisis, we report our experience in the treatment of such a patient. Case report. We report a 22-year-old male patient with clinical, pharmacological, neurophysiological, and immunological diagnosis of seropositive generalized myastenia gravis (MG) of unstable course. During the first 6 months of his disease, three deteriorations were registered, and the last one developed into a myasthenic crisis. The patient was intubated. Previous anticholinergic and imunosuppresive therapies were withdrawn, and he was treated with plasma exchange and human immunoglobulins during the crisis. After thymectomy, performed 3 weeks after extubation, the patient was stable. Conclusion. Progress in treatment of MC over the last few decades has dramatically improved its prognosis. Thymectomy is useful in the prevention of MC recurrence. |
| format | Article |
| id | doaj-art-08a5bd7cf1be41ce8e865fcd4fe75b79 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-08a5bd7cf1be41ce8e865fcd4fe75b792025-08-20T02:03:19ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202021-01-0178888788910.2298/VSP190801139M0042-84501900139MThymectomy immediately after myasthenic crisisMartić Vesna0Marić Nebojša1https://orcid.org/0000-0002-9469-8993Đorđević Dragan2Military Medical Academy, Clinic for Neurology, Belgrade, Serbia + Military Medical Academy, University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaMilitary Medical Academy, University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia + Military Medical Academy, Clinic for Thoracic Surgery, Belgrade, SerbiaMilitary Medical Academy, University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia + Military Medical Academy, Clinic for Anesthesiology and Intensive Care, Belgrade, SerbiaIntroduction. Myasthenic crisis ( MC) refers to rapid progression of myasthenic weakness accompanied by ventilatory and bulbar dysfunction. Since there is no single standard accepted in the treatment of every patient in myasthenic crisis, we report our experience in the treatment of such a patient. Case report. We report a 22-year-old male patient with clinical, pharmacological, neurophysiological, and immunological diagnosis of seropositive generalized myastenia gravis (MG) of unstable course. During the first 6 months of his disease, three deteriorations were registered, and the last one developed into a myasthenic crisis. The patient was intubated. Previous anticholinergic and imunosuppresive therapies were withdrawn, and he was treated with plasma exchange and human immunoglobulins during the crisis. After thymectomy, performed 3 weeks after extubation, the patient was stable. Conclusion. Progress in treatment of MC over the last few decades has dramatically improved its prognosis. Thymectomy is useful in the prevention of MC recurrence.http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900139M.pdfmyasthenia gravisdiagnosisthymectomycritical illnesstreatment outcome |
| spellingShingle | Martić Vesna Marić Nebojša Đorđević Dragan Thymectomy immediately after myasthenic crisis Vojnosanitetski Pregled myasthenia gravis diagnosis thymectomy critical illness treatment outcome |
| title | Thymectomy immediately after myasthenic crisis |
| title_full | Thymectomy immediately after myasthenic crisis |
| title_fullStr | Thymectomy immediately after myasthenic crisis |
| title_full_unstemmed | Thymectomy immediately after myasthenic crisis |
| title_short | Thymectomy immediately after myasthenic crisis |
| title_sort | thymectomy immediately after myasthenic crisis |
| topic | myasthenia gravis diagnosis thymectomy critical illness treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900139M.pdf |
| work_keys_str_mv | AT marticvesna thymectomyimmediatelyaftermyastheniccrisis AT maricnebojsa thymectomyimmediatelyaftermyastheniccrisis AT đorđevicdragan thymectomyimmediatelyaftermyastheniccrisis |