Gypenoside XLIX inhibiting PI3K/AKT/FOXO1 signaling pathway mediated neuronal mitochondrial autophagy to improve patients with ischemic stroke

Gypenoside XLIX inhibiting PI3K/AKT/FOXO1 signaling pathway mediated neuronal mitochondrial autophagy to improve patients with ischemic stroke

IntroductionIschemic stroke is a leading cause of mortality and disability worldwide, with limited therapeutic options and high rates of recurrence. Mitochondrial dysfunction plays a critical role in neuronal injury during ischemia-reperfusion, making mitochondrial autophagy a potential therapeutic...

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Main Authors: Yonglei Liu, Hongdie Mao, Zhengguang Sha, Jishuai Zhao, Hui Cai, Rong Xi, Zhenzhu Zhao, Xiaoling Yin, Lin Yang, Changyun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
ischemic stroke
gypenoside XLIX
mitochondrial autophagy
FoxO1
PI3K/AKT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1600435/full
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