Association of microtubule destabilization with platelet yields in terminally differentiating hiPSC-derived megakaryocyte lines.

Association of microtubule destabilization with platelet yields in terminally differentiating hiPSC-derived megakaryocyte lines.

Millions of platelet units are needed each year to manage thrombocytopenia and other conditions linked to excessive bleeding. These life-saving treatments still depend entirely on donated platelets, despite the numerous shortcomings associated with them, such as limited shelf life, supply shortages,...

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Bibliographic Details
Main Authors: Emiri Nakamura, Yasuo Harada, Trevor Bingham, Christian Skorik, Anjali Jha, John Atwater, Natsumi Higashi, Kosuke Fujio, Mariko Ishiguro, Haruki Okamoto, Leonard I Zon, George Q Daley, Andrew L Frelinger, Koji Eto, Thorsten M Schlaeger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0326165
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