Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide
Actinomycetes are a prolific source of bioactive natural compounds many of which are used as antibiotics or other drugs. In this study we investigated the genomic and biochemical diversity of 32 actinobacterial strains that had been deposited at the DSMZ–German Collection of Microorganisms and Cell...
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Elsevier
2024-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517424000737 |
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| author | Imen Nouioui Judith Boldt Alina Zimmermann Roman Makitrynskyy Gabriele Pötter Marlen Jando Meike Döppner Sarah Kirstein Meina Neumann-Schaal Juan Pablo Gomez-Escribano Ulrich Nübel Yvonne Mast |
| author_facet | Imen Nouioui Judith Boldt Alina Zimmermann Roman Makitrynskyy Gabriele Pötter Marlen Jando Meike Döppner Sarah Kirstein Meina Neumann-Schaal Juan Pablo Gomez-Escribano Ulrich Nübel Yvonne Mast |
| author_sort | Imen Nouioui |
| collection | DOAJ |
| description | Actinomycetes are a prolific source of bioactive natural compounds many of which are used as antibiotics or other drugs. In this study we investigated the genomic and biochemical diversity of 32 actinobacterial strains that had been deposited at the DSMZ–German Collection of Microorganisms and Cell Cultures decades ago. Genome-based phylogeny and in silico DNA-DNA hybridization supported the assignment of these strains to 26 novel species and two novel subspecies and a reclassification of a Streptomyces species. These results were consistent with the biochemical, enzymatic, and chemotaxonomic features of the strains. Most of the strains showed antimicrobial activities against a range of Gram-positive and Gram-negative bacteria, and against yeast. Genomic analysis revealed the presence of numerous unique biosynthetic gene clusters (BGCs) encoding for potential novel antibiotic and anti-cancer compounds. Strains DSM 41636T and DSM 61640T produced the antibiotic compounds A33853 and SF2768, respectively. Overall, this reflects the significant pharmaceutical and biotechnological potential of the proposed novel type strains and underlines the role of prokaryotic systematics for drug discovery. In order to compensate for the gender gap in naming prokaryotic species, we propose the eponyms for all newly described species to honour female scientists. |
| format | Article |
| id | doaj-art-089c83aa6dc2439ab53bf6dea3487126 |
| institution | OA Journals |
| issn | 2666-5174 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-089c83aa6dc2439ab53bf6dea34871262025-08-20T02:19:55ZengElsevierCurrent Research in Microbial Sciences2666-51742024-01-01710029010.1016/j.crmicr.2024.100290Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwideImen Nouioui0Judith Boldt1Alina Zimmermann2Roman Makitrynskyy3Gabriele Pötter4Marlen Jando5Meike Döppner6Sarah Kirstein7Meina Neumann-Schaal8Juan Pablo Gomez-Escribano9Ulrich Nübel10Yvonne Mast11Leibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany; Corresponding authors.Leibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany; German Center for Infection Research (DZIF), Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany; German Center for Infection Research (DZIF), Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany; Braunschweig Integrated Centre of Systems Biology (BRICS), Rebenring 56, 38106 Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany; German Center for Infection Research (DZIF), Braunschweig, Germany; Braunschweig Integrated Centre of Systems Biology (BRICS), Rebenring 56, 38106 Braunschweig, Germany; Technische Universität Braunschweig, Institut für Mikrobiologie, Rebenring 56, 38106 Braunschweig, GermanyLeibniz-Institut DSMZ – German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany; German Center for Infection Research (DZIF), Braunschweig, Germany; Braunschweig Integrated Centre of Systems Biology (BRICS), Rebenring 56, 38106 Braunschweig, Germany; Technische Universität Braunschweig, Institut für Mikrobiologie, Rebenring 56, 38106 Braunschweig, Germany; Corresponding authors.Actinomycetes are a prolific source of bioactive natural compounds many of which are used as antibiotics or other drugs. In this study we investigated the genomic and biochemical diversity of 32 actinobacterial strains that had been deposited at the DSMZ–German Collection of Microorganisms and Cell Cultures decades ago. Genome-based phylogeny and in silico DNA-DNA hybridization supported the assignment of these strains to 26 novel species and two novel subspecies and a reclassification of a Streptomyces species. These results were consistent with the biochemical, enzymatic, and chemotaxonomic features of the strains. Most of the strains showed antimicrobial activities against a range of Gram-positive and Gram-negative bacteria, and against yeast. Genomic analysis revealed the presence of numerous unique biosynthetic gene clusters (BGCs) encoding for potential novel antibiotic and anti-cancer compounds. Strains DSM 41636T and DSM 61640T produced the antibiotic compounds A33853 and SF2768, respectively. Overall, this reflects the significant pharmaceutical and biotechnological potential of the proposed novel type strains and underlines the role of prokaryotic systematics for drug discovery. In order to compensate for the gender gap in naming prokaryotic species, we propose the eponyms for all newly described species to honour female scientists.http://www.sciencedirect.com/science/article/pii/S2666517424000737ActinobacteriaSystematicsDrug discoveryAntibiotics |
| spellingShingle | Imen Nouioui Judith Boldt Alina Zimmermann Roman Makitrynskyy Gabriele Pötter Marlen Jando Meike Döppner Sarah Kirstein Meina Neumann-Schaal Juan Pablo Gomez-Escribano Ulrich Nübel Yvonne Mast Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide Current Research in Microbial Sciences Actinobacteria Systematics Drug discovery Antibiotics |
| title | Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide |
| title_full | Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide |
| title_fullStr | Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide |
| title_full_unstemmed | Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide |
| title_short | Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide |
| title_sort | biotechnological and pharmaceutical potential of twenty eight novel type strains of actinomycetes from different environments worldwide |
| topic | Actinobacteria Systematics Drug discovery Antibiotics |
| url | http://www.sciencedirect.com/science/article/pii/S2666517424000737 |
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