Discovery and functional characterization of canine PD-L1-targeted antibodies for evaluating antitumor efficacy in a canine osteosarcoma xenograft model

Discovery and functional characterization of canine PD-L1-targeted antibodies for evaluating antitumor efficacy in a canine osteosarcoma xenograft model

Abstract Targeting the programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway is promising in treating cancer in humans and offers potential for veterinary applications. However, no PD-L1 antibodies have been approved specifically for treating canine cancer. We aimed to dev...

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Bibliographic Details
Main Authors: Min-young Song, Jaewon Cho, Hyosung Park, Yujeong Song, Keon Kim, Jae-Hee Ahn, Chang-Min Lee, Dae Hee Kim, Hyun-Jeong Ko
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Canine cancer
Programmed death ligand 1
Immunotherapeutics
Antibody
Phage display
Online Access:https://doi.org/10.1038/s41598-025-90770-1
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