Role of Ultrasound-Based Therapies in Cardiovascular Diseases
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally, placing an immense burden on health care costs worldwide. The emergence of therapeutic ultrasound-based therapies in the CVD management represents a promising innovative strategy beyond current established a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Structural Heart |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2474870624001040 |
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| author | Amit Bansal, MBBS, PGDip, MPhil, GCert Bernard Bulwer, MD Ricarda von Krüchten, Priv.-Doz., Dr. M. Jagkirat Singh, MD Rajan Rehan, MBBS, MPH Ata Doost, MD, MPhil |
| author_facet | Amit Bansal, MBBS, PGDip, MPhil, GCert Bernard Bulwer, MD Ricarda von Krüchten, Priv.-Doz., Dr. M. Jagkirat Singh, MD Rajan Rehan, MBBS, MPH Ata Doost, MD, MPhil |
| author_sort | Amit Bansal, MBBS, PGDip, MPhil, GCert |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally, placing an immense burden on health care costs worldwide. The emergence of therapeutic ultrasound-based therapies in the CVD management represents a promising innovative strategy beyond current established approaches. This paper explores three distinct modalities of ultrasound-based therapies—high-intensity focused ultrasound, extracorporeal shock wave therapy, and low-intensity pulsed ultrasound—each characterized by unique acoustic parameters and mechanisms of action tailored to specific therapeutic outcomes. High-intensity focused ultrasound was shown to be beneficial as an adjunct in the treatment of myocardial infarction and arrhythmias. It has also been investigated for the in vivo treatment of resistant hypertension, symptomatic aortic valve stenosis, arterial stenosis, tumors, hypertrophic cardiomyopathy, and external cardiac pacing. Extracorporeal shock wave therapy was shown to be beneficial in the treatment of chronic refractory angina pectoris, while low-intensity pulsed ultrasound was shown to be beneficial in dissolving blood clots and improving blood flow in the treatment of acute pulmonary embolism, despite its association with an increased risk of bleeding. Ultrasound-based therapies are, therefore, a potential adjunct and comparatively safe adjuncts for managing challenging CVD cases. Further investigations are essential to validate their long-term effectiveness and safety, particularly for high-risk individuals susceptible to postprocedural complications. |
| format | Article |
| id | doaj-art-088f7f57855b4e988a93e1b697cda79e |
| institution | DOAJ |
| issn | 2474-8706 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Structural Heart |
| spelling | doaj-art-088f7f57855b4e988a93e1b697cda79e2025-08-20T02:46:24ZengElsevierStructural Heart2474-87062025-02-019210034910.1016/j.shj.2024.100349Role of Ultrasound-Based Therapies in Cardiovascular DiseasesAmit Bansal, MBBS, PGDip, MPhil, GCert0Bernard Bulwer, MD1Ricarda von Krüchten, Priv.-Doz., Dr. M.2Jagkirat Singh, MD3Rajan Rehan, MBBS, MPH4Ata Doost, MD, MPhil5Bergen COVID-19 Research group and Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Address correspondence to: Amit Bansal, MBBS, PGDip, MPhil, GCert, Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway NO-5020.Cardiovascular Imaging Core Laboratory, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, BostonStanford University, School of Medicine, Stanford, United States; University of Freiburg, Medical Center, Freiburg, GermanyDepartment of Neurology, Creighton University, School of Medicine, OmahaUniversity of Sydney Medical School, Sydney, AustraliaMacquarie University, Faculty of Medicine and Health Sciences and Macquarie University Hospital, Sydney, AustraliaCardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally, placing an immense burden on health care costs worldwide. The emergence of therapeutic ultrasound-based therapies in the CVD management represents a promising innovative strategy beyond current established approaches. This paper explores three distinct modalities of ultrasound-based therapies—high-intensity focused ultrasound, extracorporeal shock wave therapy, and low-intensity pulsed ultrasound—each characterized by unique acoustic parameters and mechanisms of action tailored to specific therapeutic outcomes. High-intensity focused ultrasound was shown to be beneficial as an adjunct in the treatment of myocardial infarction and arrhythmias. It has also been investigated for the in vivo treatment of resistant hypertension, symptomatic aortic valve stenosis, arterial stenosis, tumors, hypertrophic cardiomyopathy, and external cardiac pacing. Extracorporeal shock wave therapy was shown to be beneficial in the treatment of chronic refractory angina pectoris, while low-intensity pulsed ultrasound was shown to be beneficial in dissolving blood clots and improving blood flow in the treatment of acute pulmonary embolism, despite its association with an increased risk of bleeding. Ultrasound-based therapies are, therefore, a potential adjunct and comparatively safe adjuncts for managing challenging CVD cases. Further investigations are essential to validate their long-term effectiveness and safety, particularly for high-risk individuals susceptible to postprocedural complications.http://www.sciencedirect.com/science/article/pii/S2474870624001040Cardiovascular diseaseECSWTLow-intensity ultrasoundHIFUExtracorporeal cardiac shock wave therapyHigh-intensity focused ultrasound |
| spellingShingle | Amit Bansal, MBBS, PGDip, MPhil, GCert Bernard Bulwer, MD Ricarda von Krüchten, Priv.-Doz., Dr. M. Jagkirat Singh, MD Rajan Rehan, MBBS, MPH Ata Doost, MD, MPhil Role of Ultrasound-Based Therapies in Cardiovascular Diseases Structural Heart Cardiovascular disease ECSWT Low-intensity ultrasound HIFU Extracorporeal cardiac shock wave therapy High-intensity focused ultrasound |
| title | Role of Ultrasound-Based Therapies in Cardiovascular Diseases |
| title_full | Role of Ultrasound-Based Therapies in Cardiovascular Diseases |
| title_fullStr | Role of Ultrasound-Based Therapies in Cardiovascular Diseases |
| title_full_unstemmed | Role of Ultrasound-Based Therapies in Cardiovascular Diseases |
| title_short | Role of Ultrasound-Based Therapies in Cardiovascular Diseases |
| title_sort | role of ultrasound based therapies in cardiovascular diseases |
| topic | Cardiovascular disease ECSWT Low-intensity ultrasound HIFU Extracorporeal cardiac shock wave therapy High-intensity focused ultrasound |
| url | http://www.sciencedirect.com/science/article/pii/S2474870624001040 |
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