Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours
Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPARα, β, and γ, peroxisomal markers (PMP70, AOX, a...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2011/261584 |
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| author | Julieta B. Rivera-Zavala Adrián Báez-Ruiz Mauricio Díaz-Muñoz |
| author_facet | Julieta B. Rivera-Zavala Adrián Báez-Ruiz Mauricio Díaz-Muñoz |
| author_sort | Julieta B. Rivera-Zavala |
| collection | DOAJ |
| description | Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPARα, β, and γ, peroxisomal markers (PMP70, AOX, and catalase), and free fatty acids (FFAs) during RF was evaluated. The effect of fasting-refeeding was also studied. Results showed (1) higher levels of FFA before feeding, (2) a shift of PPARα and PPARγ before and of PPARβ peaks after feeding, (3) an increase in peroxisomal markers, (4) a shift of PMP70 and AOX peaks before feeding, and of maximal catalase activity in the dark period, (5) changes in the fasting-refeeding response, and (6) high correlations (>0.9) of serum corticosterone with PPARα and PPARγ and of PMP70 with PPARβ. In conclusion, 24 h rhythmicity of FFA, liver PPARs, and peroxisomal markers are biochemical adaptations associated with daytime RF and FEO expression. |
| format | Article |
| id | doaj-art-088a6c41fe174cc4b733494a24a39360 |
| institution | OA Journals |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-088a6c41fe174cc4b733494a24a393602025-08-20T02:01:34ZengWileyPPAR Research1687-47571687-47652011-01-01201110.1155/2011/261584261584Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime HoursJulieta B. Rivera-Zavala0Adrián Báez-Ruiz1Mauricio Díaz-Muñoz2Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus UNAM-Juriquilla, Querétaro 76230, QRO, MexicoDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus UNAM-Juriquilla, Querétaro 76230, QRO, MexicoDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus UNAM-Juriquilla, Querétaro 76230, QRO, MexicoRestricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPARα, β, and γ, peroxisomal markers (PMP70, AOX, and catalase), and free fatty acids (FFAs) during RF was evaluated. The effect of fasting-refeeding was also studied. Results showed (1) higher levels of FFA before feeding, (2) a shift of PPARα and PPARγ before and of PPARβ peaks after feeding, (3) an increase in peroxisomal markers, (4) a shift of PMP70 and AOX peaks before feeding, and of maximal catalase activity in the dark period, (5) changes in the fasting-refeeding response, and (6) high correlations (>0.9) of serum corticosterone with PPARα and PPARγ and of PMP70 with PPARβ. In conclusion, 24 h rhythmicity of FFA, liver PPARs, and peroxisomal markers are biochemical adaptations associated with daytime RF and FEO expression.http://dx.doi.org/10.1155/2011/261584 |
| spellingShingle | Julieta B. Rivera-Zavala Adrián Báez-Ruiz Mauricio Díaz-Muñoz Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours PPAR Research |
| title | Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal
Markers When Feeding Is Restricted to Two Daytime Hours |
| title_full | Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal
Markers When Feeding Is Restricted to Two Daytime Hours |
| title_fullStr | Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal
Markers When Feeding Is Restricted to Two Daytime Hours |
| title_full_unstemmed | Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal
Markers When Feeding Is Restricted to Two Daytime Hours |
| title_short | Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal
Markers When Feeding Is Restricted to Two Daytime Hours |
| title_sort | changes in the 24 h rhythmicity of liver ppars and peroxisomal markers when feeding is restricted to two daytime hours |
| url | http://dx.doi.org/10.1155/2011/261584 |
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