Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation
Tissue engineering and regenerative medicine are effective strategies for the treatment of damaged tissues and end-stage organ failure. Damaged tissue regeneration and organ transplantation require blood vessel reconstruction to facilitate tissue remodeling, the bottleneck for application research i...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-03-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325824000438 |
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| author | Wenya Li Zilu Xu Binghan Zou Dongcheng Yang Yue Lu Xiaohan Zhang Chen Zhang Yanzhao Li Chuhong Zhu |
| author_facet | Wenya Li Zilu Xu Binghan Zou Dongcheng Yang Yue Lu Xiaohan Zhang Chen Zhang Yanzhao Li Chuhong Zhu |
| author_sort | Wenya Li |
| collection | DOAJ |
| description | Tissue engineering and regenerative medicine are effective strategies for the treatment of damaged tissues and end-stage organ failure. Damaged tissue regeneration and organ transplantation require blood vessel reconstruction to facilitate tissue remodeling, the bottleneck for application research in this field. Immune cells are heavily involved in coordinating neovascularization, in which macrophage aggregation is a key factor in angiogenesis and arteriogenesis. Previous studies have promoted tissue vascularization by regulating macrophages; however, the mechanisms underlying macrophage-mediated vascularization remain nebulous. Studies on material-based regulation have primarily been observational and lack systematic and targeted research. Macrophages from different sources exhibit different phenotypes or functions in tissues, such as peripheral blood monocytes and tissue-resident macrophages, with each exhibiting complicated mechanisms for promoting tissue injury and graft remodeling. Therefore, in this review, we discuss the role of different tissue-resident macrophages and circulating monocytes in vascularization during injured tissue regeneration and graft remodeling and summarize the current strategies for the use of biomaterials to regulate macrophages and promote the vascularization of injured tissues and during organ transplantation. A better understanding of these mechanisms will facilitate future tissue engineering research that promotes vascularization by regulating macrophage reactions. |
| format | Article |
| id | doaj-art-0880bb10e70a49fd8b34b02afd69d532 |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-0880bb10e70a49fd8b34b02afd69d5322025-08-20T03:42:26ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-03-015269771410.1016/j.fmre.2023.12.015Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantationWenya Li0Zilu Xu1Binghan Zou2Dongcheng Yang3Yue Lu4Xiaohan Zhang5Chen Zhang6Yanzhao Li7Chuhong Zhu8Department of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, China; Laboratory of Basic Medicine, The General Hospital of Western Theater Command, Chengdu 610000, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing 400038, China; Corresponding authors.Department of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing 400038, China; Corresponding authors.Tissue engineering and regenerative medicine are effective strategies for the treatment of damaged tissues and end-stage organ failure. Damaged tissue regeneration and organ transplantation require blood vessel reconstruction to facilitate tissue remodeling, the bottleneck for application research in this field. Immune cells are heavily involved in coordinating neovascularization, in which macrophage aggregation is a key factor in angiogenesis and arteriogenesis. Previous studies have promoted tissue vascularization by regulating macrophages; however, the mechanisms underlying macrophage-mediated vascularization remain nebulous. Studies on material-based regulation have primarily been observational and lack systematic and targeted research. Macrophages from different sources exhibit different phenotypes or functions in tissues, such as peripheral blood monocytes and tissue-resident macrophages, with each exhibiting complicated mechanisms for promoting tissue injury and graft remodeling. Therefore, in this review, we discuss the role of different tissue-resident macrophages and circulating monocytes in vascularization during injured tissue regeneration and graft remodeling and summarize the current strategies for the use of biomaterials to regulate macrophages and promote the vascularization of injured tissues and during organ transplantation. A better understanding of these mechanisms will facilitate future tissue engineering research that promotes vascularization by regulating macrophage reactions.http://www.sciencedirect.com/science/article/pii/S2667325824000438MacrophageVascularizationTissue regenerationTissue engineeringGraft remodelingBiomaterials regulation |
| spellingShingle | Wenya Li Zilu Xu Binghan Zou Dongcheng Yang Yue Lu Xiaohan Zhang Chen Zhang Yanzhao Li Chuhong Zhu Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation Fundamental Research Macrophage Vascularization Tissue regeneration Tissue engineering Graft remodeling Biomaterials regulation |
| title | Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation |
| title_full | Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation |
| title_fullStr | Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation |
| title_full_unstemmed | Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation |
| title_short | Macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation |
| title_sort | macrophage regulation in vascularization upon regeneration and repair of tissue injury and engineered organ transplantation |
| topic | Macrophage Vascularization Tissue regeneration Tissue engineering Graft remodeling Biomaterials regulation |
| url | http://www.sciencedirect.com/science/article/pii/S2667325824000438 |
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