Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
Hyperactive interferon (IFN) signaling is a hallmark of Down syndrome (DS), a condition caused by Trisomy 21 (T21); strategies that normalize IFN signaling could benefit this population. Mediator-associated kinases CDK8 and CDK19 drive inflammatory responses through incompletely understood mechanism...
Saved in:
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2025-02-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/100197 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Be the first to leave a comment!