Phenolic compounds of Iris adriatica and their antimycobacterial effects
Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2019-0037 |
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| author | Ochensberger Sandra Alperth Fabian Mitić Božena Kunert Olaf Mayer Stefanie Mourão Maria Ferreira Turek Ivana Luca Simon Vlad Skalicka-Woźniak Krystyna Maleš Željan Hruševar Dario Duka Ivan Bucar Franz |
| author_facet | Ochensberger Sandra Alperth Fabian Mitić Božena Kunert Olaf Mayer Stefanie Mourão Maria Ferreira Turek Ivana Luca Simon Vlad Skalicka-Woźniak Krystyna Maleš Željan Hruševar Dario Duka Ivan Bucar Franz |
| author_sort | Ochensberger Sandra |
| collection | DOAJ |
| description | Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc2 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L−1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone, responsible for the resistance-modulatory activity of this plant. |
| format | Article |
| id | doaj-art-08682a51cd6d4d7892282890b583727a |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-08682a51cd6d4d7892282890b583727a2025-02-02T10:03:15ZengSciendoActa Pharmaceutica1846-95582019-12-0169467368110.2478/acph-2019-0037acph-2019-0037Phenolic compounds of Iris adriatica and their antimycobacterial effectsOchensberger Sandra0Alperth Fabian1Mitić Božena2Kunert Olaf3Mayer Stefanie4Mourão Maria Ferreira5Turek Ivana6Luca Simon Vlad7Skalicka-Woźniak Krystyna8Maleš Željan9Hruševar Dario10Duka Ivan11Bucar Franz12University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmacognosy, 8010GrazAustriaUniversity of Graz, Institute of Pharmaceutical Sciences, Department of Pharmacognosy, 8010GrazAustriaUniversity of Zagreb, Faculty of Science, Department of Biology (Botany), HR-10000Zagreb, CroatiaUniversity of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry8010Graz, AustriaUniversity of Graz, Institute of Pharmaceutical Sciences, Department of Pharmacognosy, 8010GrazAustriaUniversity of Lisbon, Faculty of Pharmacy, 1649-003Lisboa, PortugalUniversity of Graz, Institute of Pharmaceutical Sciences, Department of Pharmacognosy, 8010GrazAustriaDepartment of Pharmacognosy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115Iasi, RomaniaDepartment of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, 20-093LublinPolandUniversity of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical BotanyHR-10000Zagreb, CroatiaUniversity of Zagreb, Faculty of Science, Department of Biology (Botany), HR-10000Zagreb, CroatiaUniversity of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical BotanyHR-10000Zagreb, CroatiaUniversity of Graz, Institute of Pharmaceutical Sciences, Department of Pharmacognosy, 8010GrazAustriaLittle is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc2 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L−1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone, responsible for the resistance-modulatory activity of this plant.https://doi.org/10.2478/acph-2019-0037iris adriaticaradix iridisphenolic compoundsmycobacterium smegmatisresistance modulationethidium bromidemic |
| spellingShingle | Ochensberger Sandra Alperth Fabian Mitić Božena Kunert Olaf Mayer Stefanie Mourão Maria Ferreira Turek Ivana Luca Simon Vlad Skalicka-Woźniak Krystyna Maleš Željan Hruševar Dario Duka Ivan Bucar Franz Phenolic compounds of Iris adriatica and their antimycobacterial effects Acta Pharmaceutica iris adriatica radix iridis phenolic compounds mycobacterium smegmatis resistance modulation ethidium bromide mic |
| title | Phenolic compounds of Iris adriatica and their antimycobacterial effects |
| title_full | Phenolic compounds of Iris adriatica and their antimycobacterial effects |
| title_fullStr | Phenolic compounds of Iris adriatica and their antimycobacterial effects |
| title_full_unstemmed | Phenolic compounds of Iris adriatica and their antimycobacterial effects |
| title_short | Phenolic compounds of Iris adriatica and their antimycobacterial effects |
| title_sort | phenolic compounds of iris adriatica and their antimycobacterial effects |
| topic | iris adriatica radix iridis phenolic compounds mycobacterium smegmatis resistance modulation ethidium bromide mic |
| url | https://doi.org/10.2478/acph-2019-0037 |
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