Phenolic compounds of Iris adriatica and their antimycobacterial effects

Phenolic compounds of Iris adriatica and their antimycobacterial effects

Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc...

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Main Authors: Ochensberger Sandra, Alperth Fabian, Mitić Božena, Kunert Olaf, Mayer Stefanie, Mourão Maria Ferreira, Turek Ivana, Luca Simon Vlad, Skalicka-Woźniak Krystyna, Maleš Željan, Hruševar Dario, Duka Ivan, Bucar Franz
Format: Article
Language:English
Published: Sciendo 2019-12-01
Series:Acta Pharmaceutica
Subjects:
iris adriatica
radix iridis
phenolic compounds
mycobacterium smegmatis
resistance modulation
ethidium bromide
mic
Online Access:https://doi.org/10.2478/acph-2019-0037
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Summary:Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc2 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L−1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone, responsible for the resistance-modulatory activity of this plant.
ISSN:1846-9558

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