Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature
Granulosa cell tumor (GST) is a sex-cord/stromal neoplasm of the gonads, more commonly arising in the ovaries, while approximately 80 cases have been reported in the testes. Out of these, 30 cases were of the adult type, while the remainder 50 cases were of the juvenile type. The latter mostly conce...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2013/932086 |
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| author | Dimosthenis Miliaras Eleftherios Anagnostou Ioannis Moysides |
| author_facet | Dimosthenis Miliaras Eleftherios Anagnostou Ioannis Moysides |
| author_sort | Dimosthenis Miliaras |
| collection | DOAJ |
| description | Granulosa cell tumor (GST) is a sex-cord/stromal neoplasm of the gonads, more commonly arising in the ovaries, while approximately 80 cases have been reported in the testes. Out of these, 30 cases were of the adult type, while the remainder 50 cases were of the juvenile type. The latter mostly concerned infants and followed a benign course. However, the adult type testicular GCTs may be potentially malignant as it also happens in female patients with such neoplasms. We present a case of an adult type GCT located at the left testis. The patient was subjected to total orchiectomy and received no further treatment. Histology showed typical GCT histomorphology with Call-Exner bodies in some places. The immunoprofile of the tumor was CD99 (+), calretinin (+), inhibin (+), alpha smooth muscle actin (+), vimentin (+), ER (−), PR (−), keratin AE1/AE3 (−), alpha fetoprotein (−), CD117 (−), and placental alkaline phosphatase (−). Two years after surgery, the patient is alive and well with no signs of recurrence. |
| format | Article |
| id | doaj-art-086219ed936448208bb4118cc752b0e4 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-086219ed936448208bb4118cc752b0e42025-02-03T06:06:09ZengWileyCase Reports in Pathology2090-67812090-679X2013-01-01201310.1155/2013/932086932086Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the LiteratureDimosthenis Miliaras0Eleftherios Anagnostou1Ioannis Moysides2Laboratory of Histology and Embryology, Faculty of Medicine, Aristotle University of Thessaloniki, 54006 Thessaloniki, GreeceDepartment of Pathology, Euromedica Geniki Kliniki of Thessaloniki, 2 Gravias Street, 54645 Thessaloniki, GreeceDepartment of Pathology, Euromedica Geniki Kliniki of Thessaloniki, 2 Gravias Street, 54645 Thessaloniki, GreeceGranulosa cell tumor (GST) is a sex-cord/stromal neoplasm of the gonads, more commonly arising in the ovaries, while approximately 80 cases have been reported in the testes. Out of these, 30 cases were of the adult type, while the remainder 50 cases were of the juvenile type. The latter mostly concerned infants and followed a benign course. However, the adult type testicular GCTs may be potentially malignant as it also happens in female patients with such neoplasms. We present a case of an adult type GCT located at the left testis. The patient was subjected to total orchiectomy and received no further treatment. Histology showed typical GCT histomorphology with Call-Exner bodies in some places. The immunoprofile of the tumor was CD99 (+), calretinin (+), inhibin (+), alpha smooth muscle actin (+), vimentin (+), ER (−), PR (−), keratin AE1/AE3 (−), alpha fetoprotein (−), CD117 (−), and placental alkaline phosphatase (−). Two years after surgery, the patient is alive and well with no signs of recurrence.http://dx.doi.org/10.1155/2013/932086 |
| spellingShingle | Dimosthenis Miliaras Eleftherios Anagnostou Ioannis Moysides Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature Case Reports in Pathology |
| title | Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature |
| title_full | Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature |
| title_fullStr | Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature |
| title_full_unstemmed | Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature |
| title_short | Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature |
| title_sort | adult type granulosa cell tumor a very rare case of sex cord tumor of the testis with review of the literature |
| url | http://dx.doi.org/10.1155/2013/932086 |
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