Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer
Background: n-ELAV (neuronal-Embryonic Lethal, Abnormal Vision)-like genes belong to a family codifying for onconeural RNA-binding proteins. Anti-Hu-antibodies (anti-Hu-Ab) are typically associated with paraneoplastic encephalomyelitis/sensory neuropathy (PEM/PSN), and low titres of anti-Hu-Ab, were...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2008-0424 |
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| _version_ | 1832561957013553152 |
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| author | Vito D’Alessandro Lucia Anna Muscarella Massimiliano Copetti Leopoldo Zelante Massimo Carella Gianluigi Vendemiale |
| author_facet | Vito D’Alessandro Lucia Anna Muscarella Massimiliano Copetti Leopoldo Zelante Massimo Carella Gianluigi Vendemiale |
| author_sort | Vito D’Alessandro |
| collection | DOAJ |
| description | Background: n-ELAV (neuronal-Embryonic Lethal, Abnormal Vision)-like genes belong to a family codifying for onconeural RNA-binding proteins. Anti-Hu-antibodies (anti-Hu-Ab) are typically associated with paraneoplastic encephalomyelitis/sensory neuropathy (PEM/PSN), and low titres of anti-Hu-Ab, were found in newly diagnosed Small Cell Lung Cancer (SCLC). The aim of this study is to develop a sensitive and quantitative molecular real-time PCR assay to detect SCLC cells in peripheral blood (PB) through nELAV-like transcripts quantification. |
| format | Article |
| id | doaj-art-0861dea2745d415a8ed0d21ce646d8b4 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-0861dea2745d415a8ed0d21ce646d8b42025-02-03T01:23:42ZengWileyCellular Oncology1570-58701875-86062008-01-0130429129710.3233/CLO-2008-0424Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung CancerVito D’Alessandro0Lucia Anna Muscarella1Massimiliano Copetti2Leopoldo Zelante3Massimo Carella4Gianluigi Vendemiale5Internal Medicine Department, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG), ItalyInternal Medicine Department, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG), ItalyInstitute of Quantitative Methods, “L. Bocconi” University, Milano, ItalyEvolutive Age Department, Medical Genetics Service, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG), ItalyEvolutive Age Department, Medical Genetics Service, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG), ItalyInternal Medicine Department, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo (FG), ItalyBackground: n-ELAV (neuronal-Embryonic Lethal, Abnormal Vision)-like genes belong to a family codifying for onconeural RNA-binding proteins. Anti-Hu-antibodies (anti-Hu-Ab) are typically associated with paraneoplastic encephalomyelitis/sensory neuropathy (PEM/PSN), and low titres of anti-Hu-Ab, were found in newly diagnosed Small Cell Lung Cancer (SCLC). The aim of this study is to develop a sensitive and quantitative molecular real-time PCR assay to detect SCLC cells in peripheral blood (PB) through nELAV-like transcripts quantification.http://dx.doi.org/10.3233/CLO-2008-0424 |
| spellingShingle | Vito D’Alessandro Lucia Anna Muscarella Massimiliano Copetti Leopoldo Zelante Massimo Carella Gianluigi Vendemiale Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer Cellular Oncology |
| title | Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer |
| title_full | Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer |
| title_fullStr | Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer |
| title_full_unstemmed | Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer |
| title_short | Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer |
| title_sort | molecular detection of neuron specific elav like positive cells in the peripheral blood of patients with small cell lung cancer |
| url | http://dx.doi.org/10.3233/CLO-2008-0424 |
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