Investigation of some chemotherapy drugs induce cardiotoxicity
The risk of long-term cardiovascular problems resulting from cancer treatment is rising due to the growing population of cancer patients. Cancer therapy-induced cardiotoxicity (CTIC) is a partially elucidated consequence of diverse chemotherapeutic drugs, targeted anti-cancer treatments, and radiat...
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Alsalam university college
2025-08-01
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| Series: | Al-SalamJournal for Medical Science |
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| Online Access: | http://journal.alsalam.edu.iq/index.php/ajbms/article/view/470 |
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| author | Asia A. Mahdi Basma H. Bedair Ashjan M. Hussein Alyaa K. Abood Rabiah M. Sabri Shams A. Mohammed Eman G. Metaab Reem H. Al-Tabra Nada H. Bedair Moustafa A. Gouda Asmaa A. Jawad Abbas K. Abbas |
| author_facet | Asia A. Mahdi Basma H. Bedair Ashjan M. Hussein Alyaa K. Abood Rabiah M. Sabri Shams A. Mohammed Eman G. Metaab Reem H. Al-Tabra Nada H. Bedair Moustafa A. Gouda Asmaa A. Jawad Abbas K. Abbas |
| author_sort | Asia A. Mahdi |
| collection | DOAJ |
| description |
The risk of long-term cardiovascular problems resulting from cancer treatment is rising due to the growing population of cancer patients. Cancer therapy-induced cardiotoxicity (CTIC) is a partially elucidated consequence of diverse chemotherapeutic drugs, targeted anti-cancer treatments, and radiation treatment. It is usually identified clinically by a decrease in left ventricular ejection fraction, evaluated by echocardiography. Nonetheless, the emergence of cardiac functional decline signifies irreparable heart injury, underscoring the need for the development of diagnostics capable of identifying CTIC before the commencement of functional deterioration. Growing evidence indicates that abnormal changes in heart metabolism significantly contribute to the onset of CTIC. The treatment progress has significantly enhanced the recovery rate of cancer patients. This better longevity is concomitant with increased risks for cardiovascular complications. Chemotherapy-induced cardiotoxicity is a perilous outcome that limits the therapeutic use of various chemotherapy agents. This review analyses the prevalence of heart disease is caused by immunotherapeutic medicines and chemotherapy. The preventive characteristics of antioxidants and future possible concerns about cardiotoxicities caused by treatment are the primary topics of discussion in this study.
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| format | Article |
| id | doaj-art-0861ab05cce14a66b3d00a9ec9916cc1 |
| institution | Kabale University |
| issn | 2958-0870 2959-5398 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Alsalam university college |
| record_format | Article |
| series | Al-SalamJournal for Medical Science |
| spelling | doaj-art-0861ab05cce14a66b3d00a9ec9916cc12025-08-23T14:53:16ZengAlsalam university collegeAl-SalamJournal for Medical Science2958-08702959-53982025-08-014210.55145/ajbms.2025.04.02.001Investigation of some chemotherapy drugs induce cardiotoxicityAsia A. Mahdi0Basma H. Bedair1Ashjan M. Hussein2Alyaa K. Abood3Rabiah M. Sabri4Shams A. Mohammed5Eman G. Metaab6Reem H. Al-Tabra7Nada H. Bedair8Moustafa A. Gouda9Asmaa A. Jawad10Abbas K. Abbas11Department of Forensic Biology, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq.Department of Experimental Therapy, Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.Department of Forensic Biology, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq.Department of Forensic Engineering, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq.Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia. Department of Chemistry, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq.Muthana Agriculture Directorate, Ministry of Agriculture, Al-Muthana, Iraq. The risk of long-term cardiovascular problems resulting from cancer treatment is rising due to the growing population of cancer patients. Cancer therapy-induced cardiotoxicity (CTIC) is a partially elucidated consequence of diverse chemotherapeutic drugs, targeted anti-cancer treatments, and radiation treatment. It is usually identified clinically by a decrease in left ventricular ejection fraction, evaluated by echocardiography. Nonetheless, the emergence of cardiac functional decline signifies irreparable heart injury, underscoring the need for the development of diagnostics capable of identifying CTIC before the commencement of functional deterioration. Growing evidence indicates that abnormal changes in heart metabolism significantly contribute to the onset of CTIC. The treatment progress has significantly enhanced the recovery rate of cancer patients. This better longevity is concomitant with increased risks for cardiovascular complications. Chemotherapy-induced cardiotoxicity is a perilous outcome that limits the therapeutic use of various chemotherapy agents. This review analyses the prevalence of heart disease is caused by immunotherapeutic medicines and chemotherapy. The preventive characteristics of antioxidants and future possible concerns about cardiotoxicities caused by treatment are the primary topics of discussion in this study. http://journal.alsalam.edu.iq/index.php/ajbms/article/view/470Cardiotoxicity; Chemotherapy; Heart failure; Cardio protection; CTIC |
| spellingShingle | Asia A. Mahdi Basma H. Bedair Ashjan M. Hussein Alyaa K. Abood Rabiah M. Sabri Shams A. Mohammed Eman G. Metaab Reem H. Al-Tabra Nada H. Bedair Moustafa A. Gouda Asmaa A. Jawad Abbas K. Abbas Investigation of some chemotherapy drugs induce cardiotoxicity Al-SalamJournal for Medical Science Cardiotoxicity; Chemotherapy; Heart failure; Cardio protection; CTIC |
| title | Investigation of some chemotherapy drugs induce cardiotoxicity |
| title_full | Investigation of some chemotherapy drugs induce cardiotoxicity |
| title_fullStr | Investigation of some chemotherapy drugs induce cardiotoxicity |
| title_full_unstemmed | Investigation of some chemotherapy drugs induce cardiotoxicity |
| title_short | Investigation of some chemotherapy drugs induce cardiotoxicity |
| title_sort | investigation of some chemotherapy drugs induce cardiotoxicity |
| topic | Cardiotoxicity; Chemotherapy; Heart failure; Cardio protection; CTIC |
| url | http://journal.alsalam.edu.iq/index.php/ajbms/article/view/470 |
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