BAX-mediated ammonia-driven cell death: a novel prognostic and therapeutic target in clear cell renal cell carcinoma

BAX-mediated ammonia-driven cell death: a novel prognostic and therapeutic target in clear cell renal cell carcinoma

Abstract Background ccRCC (clear cell renal cell carcinoma) is characterized by metabolic reprogramming and immunosuppression, leading to poor clinical prognosis. In recent years, ammonia-related cell death has attracted increasing attention as a novel mechanism related to tumor progression, but its...

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Bibliographic Details
Main Authors: Xi Zhang, Zijie Yu, Lu Yin, Qiang Li, Shaohua He, Heng Li, Jian Li, Lian Sheng, Hongfei Wu, Hongqi Chen, Xiaoxu Zhu, Yang Lv
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Human Genomics
Subjects:
Clear cell renal cell carcinoma
Ammonia-related cell death
Prognostic characteristics
BAX
Single-cell RNA sequencing
Online Access:https://doi.org/10.1186/s40246-025-00764-3
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