Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney Disease
Acute kidney injury (AKI) is a major but often underestimated risk factor for the development of chronic kidney disease (CKD). Exploring innovative approaches to prevent this progression is critical. Intermittent fasting (IF), recognized for its metabolic and anti-inflammatory benefits, may offer pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/1/119 |
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| author | Yoonjoo Jang Young Suk Kim Seo Rin Kim Dong Won Lee Soo Bong Lee Il Young Kim |
| author_facet | Yoonjoo Jang Young Suk Kim Seo Rin Kim Dong Won Lee Soo Bong Lee Il Young Kim |
| author_sort | Yoonjoo Jang |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a major but often underestimated risk factor for the development of chronic kidney disease (CKD). Exploring innovative approaches to prevent this progression is critical. Intermittent fasting (IF), recognized for its metabolic and anti-inflammatory benefits, may offer protective effects in this context. Using a unilateral ischemia-reperfusion injury (UIRI) model in male C57BL/6 mice, we evaluated the impact of IF on tubulointerstitial fibrosis and tubular epithelial–mesenchymal transition (EMT) over 8 weeks. Mice in the IF group followed a 5:2 regimen, fasting for 24 h twice weekly. Four groups were studied: control, IF, UIRI, and IF + UIRI. The UIRI group exhibited increased fibrosis and EMT, both of which were significantly attenuated in the IF + UIRI group. IF also reduced levels of TGF-β1, phosphorylated NF-κB p65, inflammatory cytokines, and F4/80-positive macrophages, along with markers of oxidative stress. These findings highlight IF’s ability to mitigate fibrosis and EMT through reductions in inflammation and oxidative stress during AKI-to-CKD progression. Our study suggests that IF may serve as a promising dietary strategy to prevent AKI from advancing into CKD. |
| format | Article |
| id | doaj-art-0858ab33d84d4be39a370bd81b2801d3 |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-0858ab33d84d4be39a370bd81b2801d32025-01-24T13:19:32ZengMDPI AGAntioxidants2076-39212025-01-0114111910.3390/antiox14010119Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney DiseaseYoonjoo Jang0Young Suk Kim1Seo Rin Kim2Dong Won Lee3Soo Bong Lee4Il Young Kim5Department of Internal Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of KoreaResearch Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of KoreaAcute kidney injury (AKI) is a major but often underestimated risk factor for the development of chronic kidney disease (CKD). Exploring innovative approaches to prevent this progression is critical. Intermittent fasting (IF), recognized for its metabolic and anti-inflammatory benefits, may offer protective effects in this context. Using a unilateral ischemia-reperfusion injury (UIRI) model in male C57BL/6 mice, we evaluated the impact of IF on tubulointerstitial fibrosis and tubular epithelial–mesenchymal transition (EMT) over 8 weeks. Mice in the IF group followed a 5:2 regimen, fasting for 24 h twice weekly. Four groups were studied: control, IF, UIRI, and IF + UIRI. The UIRI group exhibited increased fibrosis and EMT, both of which were significantly attenuated in the IF + UIRI group. IF also reduced levels of TGF-β1, phosphorylated NF-κB p65, inflammatory cytokines, and F4/80-positive macrophages, along with markers of oxidative stress. These findings highlight IF’s ability to mitigate fibrosis and EMT through reductions in inflammation and oxidative stress during AKI-to-CKD progression. Our study suggests that IF may serve as a promising dietary strategy to prevent AKI from advancing into CKD.https://www.mdpi.com/2076-3921/14/1/119acute kidney injurychronic kidney diseaseepithelial–mesenchymal transitionintermittent fastingtubulointerstitial fibrosis |
| spellingShingle | Yoonjoo Jang Young Suk Kim Seo Rin Kim Dong Won Lee Soo Bong Lee Il Young Kim Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney Disease Antioxidants acute kidney injury chronic kidney disease epithelial–mesenchymal transition intermittent fasting tubulointerstitial fibrosis |
| title | Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney Disease |
| title_full | Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney Disease |
| title_fullStr | Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney Disease |
| title_full_unstemmed | Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney Disease |
| title_short | Intermittent Fasting Protects Against the Progression from Acute Kidney Injury to Chronic Kidney Disease |
| title_sort | intermittent fasting protects against the progression from acute kidney injury to chronic kidney disease |
| topic | acute kidney injury chronic kidney disease epithelial–mesenchymal transition intermittent fasting tubulointerstitial fibrosis |
| url | https://www.mdpi.com/2076-3921/14/1/119 |
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