The effects of mitochondrial damage and energy metabolism disorders on the progression of noise-induced deafness and its treatment
Abstract Noise-induced hearing loss (NIHL) is a major cause of hearing impairment globally, affecting numerous individuals. The pathogenesis of NIHL is complex, involving multiple mechanisms such as mechanical damage, oxidative stress, mitochondrial dysfunction, and energy metabolism disorders. Alth...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
|
| Series: | Head & Face Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13005-025-00532-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849234363613446144 |
|---|---|
| author | LuHua Xu HongYan Jiang |
| author_facet | LuHua Xu HongYan Jiang |
| author_sort | LuHua Xu |
| collection | DOAJ |
| description | Abstract Noise-induced hearing loss (NIHL) is a major cause of hearing impairment globally, affecting numerous individuals. The pathogenesis of NIHL is complex, involving multiple mechanisms such as mechanical damage, oxidative stress, mitochondrial dysfunction, and energy metabolism disorders. Although these mechanisms are implicated, the complete understanding of NIHL’s pathogenesis remains elusive. In recent years, the role of mitochondrial dysfunction and energy metabolism disorders in NIHL has garnered significant attention. This review aims to provide a comprehensive summary of the pathological mechanisms underlying NIHL, focusing on the contributions of mitochondrial damage and energy metabolism disorders. Moreover, this review evaluates existing therapeutic approaches and proposes future research directions through critical analysis of published evidence. |
| format | Article |
| id | doaj-art-08565d47529f4ffbabc8eb2f6ade7c48 |
| institution | Kabale University |
| issn | 1746-160X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Head & Face Medicine |
| spelling | doaj-art-08565d47529f4ffbabc8eb2f6ade7c482025-08-20T04:03:11ZengBMCHead & Face Medicine1746-160X2025-08-0121111210.1186/s13005-025-00532-7The effects of mitochondrial damage and energy metabolism disorders on the progression of noise-induced deafness and its treatmentLuHua Xu0HongYan Jiang1Department of Otolaryngology-Head and Neck Surgery, Hainan Medical University Hainan HospitalDepartment of Otolaryngology-Head and Neck Surgery, Hainan Medical University Hainan HospitalAbstract Noise-induced hearing loss (NIHL) is a major cause of hearing impairment globally, affecting numerous individuals. The pathogenesis of NIHL is complex, involving multiple mechanisms such as mechanical damage, oxidative stress, mitochondrial dysfunction, and energy metabolism disorders. Although these mechanisms are implicated, the complete understanding of NIHL’s pathogenesis remains elusive. In recent years, the role of mitochondrial dysfunction and energy metabolism disorders in NIHL has garnered significant attention. This review aims to provide a comprehensive summary of the pathological mechanisms underlying NIHL, focusing on the contributions of mitochondrial damage and energy metabolism disorders. Moreover, this review evaluates existing therapeutic approaches and proposes future research directions through critical analysis of published evidence.https://doi.org/10.1186/s13005-025-00532-7Noise-induced hearing lossMitochondrial damageEnergy metabolism disorderMechanismTreatmentResearch progress |
| spellingShingle | LuHua Xu HongYan Jiang The effects of mitochondrial damage and energy metabolism disorders on the progression of noise-induced deafness and its treatment Head & Face Medicine Noise-induced hearing loss Mitochondrial damage Energy metabolism disorder Mechanism Treatment Research progress |
| title | The effects of mitochondrial damage and energy metabolism disorders on the progression of noise-induced deafness and its treatment |
| title_full | The effects of mitochondrial damage and energy metabolism disorders on the progression of noise-induced deafness and its treatment |
| title_fullStr | The effects of mitochondrial damage and energy metabolism disorders on the progression of noise-induced deafness and its treatment |
| title_full_unstemmed | The effects of mitochondrial damage and energy metabolism disorders on the progression of noise-induced deafness and its treatment |
| title_short | The effects of mitochondrial damage and energy metabolism disorders on the progression of noise-induced deafness and its treatment |
| title_sort | effects of mitochondrial damage and energy metabolism disorders on the progression of noise induced deafness and its treatment |
| topic | Noise-induced hearing loss Mitochondrial damage Energy metabolism disorder Mechanism Treatment Research progress |
| url | https://doi.org/10.1186/s13005-025-00532-7 |
| work_keys_str_mv | AT luhuaxu theeffectsofmitochondrialdamageandenergymetabolismdisordersontheprogressionofnoiseinduceddeafnessanditstreatment AT hongyanjiang theeffectsofmitochondrialdamageandenergymetabolismdisordersontheprogressionofnoiseinduceddeafnessanditstreatment AT luhuaxu effectsofmitochondrialdamageandenergymetabolismdisordersontheprogressionofnoiseinduceddeafnessanditstreatment AT hongyanjiang effectsofmitochondrialdamageandenergymetabolismdisordersontheprogressionofnoiseinduceddeafnessanditstreatment |