Pregnancy Outcome and Postnatal Chromosome Analysis of the Cord Blood and Chorionic Villi in Two Cases after Intrauterine Transfer of Mosaic Aneuploid Blastocysts
The long-term prognosis and genetic mechanism of pregnancy after intrauterine mosaic aneuploid blastocyst transfer remain unknown. We report the case of two babies after the aforementioned procedure and chromosomal analysis of their cord blood and chorionic villi. Case Report 1. A 41-year-old primip...
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Wiley
2022-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2022/1763948 |
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| author | Yuki Ito Taizan Kamide Kosuke Taniguchi Taisuke Sato Michihiro Yamamura Akiko Konishi Ken Takahashi Hiroshi Kishi Kenichiro Hata Osamu Samura Aikou Okamoto |
| author_facet | Yuki Ito Taizan Kamide Kosuke Taniguchi Taisuke Sato Michihiro Yamamura Akiko Konishi Ken Takahashi Hiroshi Kishi Kenichiro Hata Osamu Samura Aikou Okamoto |
| author_sort | Yuki Ito |
| collection | DOAJ |
| description | The long-term prognosis and genetic mechanism of pregnancy after intrauterine mosaic aneuploid blastocyst transfer remain unknown. We report the case of two babies after the aforementioned procedure and chromosomal analysis of their cord blood and chorionic villi. Case Report 1. A 41-year-old primipara, with two previous spontaneous abortions, was pregnant after intrauterine transfer of a blastocyst carrying 40% mosaicism of long-arm monosomy of chromosome 5. The amniocentesis results were 46,XX. A cesarean section was performed at 39 weeks. The female infant was 3,315 g at birth. Case Report 2. A 44-year-old primipara, with two spontaneous abortions, was pregnant after intrauterine transfer of a blastocyst carrying 40% mosaicism of long-arm monosomy of chromosome 9 and monosomy of chromosome 14. After genetic counselling, she decided not to undergo amniocentesis. No abnormalities were found by ultrasound. A cesarean section was performed at 38 weeks. The male infant was 3,340 g at birth. Chromosome analyses of postnatal cord blood and chorionic villi were performed using SNP arrays. The cord blood and chorionic villi showed no chromosomal structural abnormalities or mosaicism. For both, no disorders were observed at 10 months of age. We experienced the birth of babies after intrauterine transfer of mosaic aneuploid blastocysts. |
| format | Article |
| id | doaj-art-0855edecbcbf428da271e136e0c0cdb6 |
| institution | OA Journals |
| issn | 2090-6692 |
| language | English |
| publishDate | 2022-01-01 |
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| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-0855edecbcbf428da271e136e0c0cdb62025-08-20T02:01:35ZengWileyCase Reports in Obstetrics and Gynecology2090-66922022-01-01202210.1155/2022/1763948Pregnancy Outcome and Postnatal Chromosome Analysis of the Cord Blood and Chorionic Villi in Two Cases after Intrauterine Transfer of Mosaic Aneuploid BlastocystsYuki Ito0Taizan Kamide1Kosuke Taniguchi2Taisuke Sato3Michihiro Yamamura4Akiko Konishi5Ken Takahashi6Hiroshi Kishi7Kenichiro Hata8Osamu Samura9Aikou Okamoto10Department of Obstetrics and GynaecologyDepartment of Obstetrics and GynaecologyDepartment of Maternal-Fetal BiologyDepartment of Obstetrics and GynaecologyDepartment of Obstetrics and GynaecologyDepartment of Obstetrics and GynaecologyDepartment of Obstetrics and GynaecologyDepartment of Obstetrics and GynaecologyDepartment of Maternal-Fetal BiologyDepartment of Obstetrics and GynaecologyDepartment of Obstetrics and GynaecologyThe long-term prognosis and genetic mechanism of pregnancy after intrauterine mosaic aneuploid blastocyst transfer remain unknown. We report the case of two babies after the aforementioned procedure and chromosomal analysis of their cord blood and chorionic villi. Case Report 1. A 41-year-old primipara, with two previous spontaneous abortions, was pregnant after intrauterine transfer of a blastocyst carrying 40% mosaicism of long-arm monosomy of chromosome 5. The amniocentesis results were 46,XX. A cesarean section was performed at 39 weeks. The female infant was 3,315 g at birth. Case Report 2. A 44-year-old primipara, with two spontaneous abortions, was pregnant after intrauterine transfer of a blastocyst carrying 40% mosaicism of long-arm monosomy of chromosome 9 and monosomy of chromosome 14. After genetic counselling, she decided not to undergo amniocentesis. No abnormalities were found by ultrasound. A cesarean section was performed at 38 weeks. The male infant was 3,340 g at birth. Chromosome analyses of postnatal cord blood and chorionic villi were performed using SNP arrays. The cord blood and chorionic villi showed no chromosomal structural abnormalities or mosaicism. For both, no disorders were observed at 10 months of age. We experienced the birth of babies after intrauterine transfer of mosaic aneuploid blastocysts.http://dx.doi.org/10.1155/2022/1763948 |
| spellingShingle | Yuki Ito Taizan Kamide Kosuke Taniguchi Taisuke Sato Michihiro Yamamura Akiko Konishi Ken Takahashi Hiroshi Kishi Kenichiro Hata Osamu Samura Aikou Okamoto Pregnancy Outcome and Postnatal Chromosome Analysis of the Cord Blood and Chorionic Villi in Two Cases after Intrauterine Transfer of Mosaic Aneuploid Blastocysts Case Reports in Obstetrics and Gynecology |
| title | Pregnancy Outcome and Postnatal Chromosome Analysis of the Cord Blood and Chorionic Villi in Two Cases after Intrauterine Transfer of Mosaic Aneuploid Blastocysts |
| title_full | Pregnancy Outcome and Postnatal Chromosome Analysis of the Cord Blood and Chorionic Villi in Two Cases after Intrauterine Transfer of Mosaic Aneuploid Blastocysts |
| title_fullStr | Pregnancy Outcome and Postnatal Chromosome Analysis of the Cord Blood and Chorionic Villi in Two Cases after Intrauterine Transfer of Mosaic Aneuploid Blastocysts |
| title_full_unstemmed | Pregnancy Outcome and Postnatal Chromosome Analysis of the Cord Blood and Chorionic Villi in Two Cases after Intrauterine Transfer of Mosaic Aneuploid Blastocysts |
| title_short | Pregnancy Outcome and Postnatal Chromosome Analysis of the Cord Blood and Chorionic Villi in Two Cases after Intrauterine Transfer of Mosaic Aneuploid Blastocysts |
| title_sort | pregnancy outcome and postnatal chromosome analysis of the cord blood and chorionic villi in two cases after intrauterine transfer of mosaic aneuploid blastocysts |
| url | http://dx.doi.org/10.1155/2022/1763948 |
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