The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database
Abstract Objective To analyze the expression and significance of resistin (RETN) in pan-cancer and determine the prospect of RETN as a biomarker for STAD, providing a new diagnostic and therapeutic target for STAD. Methods Based on the RNA-seq data from the TCGA database, RETN was comprehensively an...
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Springer
2025-05-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02755-1 |
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| author | Yaxing Deng Chenglin Wang Rui Yang Qingqiang Yang |
| author_facet | Yaxing Deng Chenglin Wang Rui Yang Qingqiang Yang |
| author_sort | Yaxing Deng |
| collection | DOAJ |
| description | Abstract Objective To analyze the expression and significance of resistin (RETN) in pan-cancer and determine the prospect of RETN as a biomarker for STAD, providing a new diagnostic and therapeutic target for STAD. Methods Based on the RNA-seq data from the TCGA database, RETN was comprehensively analyzed from the perspective of pan-cancer. Firstly, the expression of RETN, correlation of immune infiltration, diagnostic efficacy and prognostic value in pan-cancer were investigated. Subsequently, the potential value of RETN as a biomarker for STAD was evaluated. Finally, the potential mechanisms of RETN in STAD were explored, including single-cell expression, PPI, functional enrichment analysis, single-gene correlation, gene co-expression analysis, and immune infiltration correlation. Results RETN is upregulated in most tumors and is associated with a variety of immune cells. As a potential biomarker, RETN showed good diagnostic efficacy and prognostic value in a variety of tumors. The prediction model based on pathological stage, sex, age and RETN has a good prediction effect on the overall survival of STAD patients. Single-cell expression analysis showed that RETN was mainly expressed by DC cells and mononuclear/macrophage cells in STAD. Subsequently, RETN and related genes were analyzed from the perspective of PPI and functional enrichment, and the results showed that these genes/proteins were mainly involved in regulating hormone secretion and insulin response. Finally, RETN is also closely associated with immune cells in STAD. Conclusions RETN is a promising biomarker related to the diagnosis and prognosis of STAD, and is expected to become a new diagnostic and therapeutic target for STAD. |
| format | Article |
| id | doaj-art-08542d30f68e43cf884a565541a67154 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-08542d30f68e43cf884a565541a671542025-08-20T02:03:36ZengSpringerDiscover Oncology2730-60112025-05-0116112910.1007/s12672-025-02755-1The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA databaseYaxing Deng0Chenglin Wang1Rui Yang2Qingqiang Yang3Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical UniversityDepartment of Emergency Medicine, The Affiliated Hospital of Southwest Medical UniversityDepartment of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical UniversityDepartment of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical UniversityAbstract Objective To analyze the expression and significance of resistin (RETN) in pan-cancer and determine the prospect of RETN as a biomarker for STAD, providing a new diagnostic and therapeutic target for STAD. Methods Based on the RNA-seq data from the TCGA database, RETN was comprehensively analyzed from the perspective of pan-cancer. Firstly, the expression of RETN, correlation of immune infiltration, diagnostic efficacy and prognostic value in pan-cancer were investigated. Subsequently, the potential value of RETN as a biomarker for STAD was evaluated. Finally, the potential mechanisms of RETN in STAD were explored, including single-cell expression, PPI, functional enrichment analysis, single-gene correlation, gene co-expression analysis, and immune infiltration correlation. Results RETN is upregulated in most tumors and is associated with a variety of immune cells. As a potential biomarker, RETN showed good diagnostic efficacy and prognostic value in a variety of tumors. The prediction model based on pathological stage, sex, age and RETN has a good prediction effect on the overall survival of STAD patients. Single-cell expression analysis showed that RETN was mainly expressed by DC cells and mononuclear/macrophage cells in STAD. Subsequently, RETN and related genes were analyzed from the perspective of PPI and functional enrichment, and the results showed that these genes/proteins were mainly involved in regulating hormone secretion and insulin response. Finally, RETN is also closely associated with immune cells in STAD. Conclusions RETN is a promising biomarker related to the diagnosis and prognosis of STAD, and is expected to become a new diagnostic and therapeutic target for STAD.https://doi.org/10.1007/s12672-025-02755-1Resistin (RETN)Pan-cancerSTADBiomarkerThe TCGA database |
| spellingShingle | Yaxing Deng Chenglin Wang Rui Yang Qingqiang Yang The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database Discover Oncology Resistin (RETN) Pan-cancer STAD Biomarker The TCGA database |
| title | The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database |
| title_full | The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database |
| title_fullStr | The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database |
| title_full_unstemmed | The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database |
| title_short | The role of RETN in stomach adenocarcinoma (STAD): insights from pan-cancer analysis of RNA-seq data based on the TCGA database |
| title_sort | role of retn in stomach adenocarcinoma stad insights from pan cancer analysis of rna seq data based on the tcga database |
| topic | Resistin (RETN) Pan-cancer STAD Biomarker The TCGA database |
| url | https://doi.org/10.1007/s12672-025-02755-1 |
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