Peripheral Neuropathy and Tear Film Dysfunction in Type 1 Diabetes Mellitus
Purpose. To compare tear film metrics in patients with type 1 diabetes mellitus (DM) and healthy controls and investigate the association between peripheral neuropathy and ocular surface quality. Methods. Dry eye symptoms were quantified in 53 patients with type 1 DM and 40 age-matched controls. Ocu...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/848659 |
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| author | Stuti L. Misra Dipika V. Patel Charles N. J. McGhee Monika Pradhan Dean Kilfoyle Geoffrey D. Braatvedt Jennifer P. Craig |
| author_facet | Stuti L. Misra Dipika V. Patel Charles N. J. McGhee Monika Pradhan Dean Kilfoyle Geoffrey D. Braatvedt Jennifer P. Craig |
| author_sort | Stuti L. Misra |
| collection | DOAJ |
| description | Purpose. To compare tear film metrics in patients with type 1 diabetes mellitus (DM) and healthy controls and investigate the association between peripheral neuropathy and ocular surface quality. Methods. Dry eye symptoms were quantified in 53 patients with type 1 DM and 40 age-matched controls. Ocular examination included tear film lipid layer thickness grading, tear film stability and quantity measurement, and retinal photography. DM individuals additionally underwent a detailed neuropathy assessment. Results. Neither mean age nor dry eye symptom scores differed significantly between the DM and control groups (P=0.12 and P=0.33, resp.). Tear lipid thickness (P=0.02), stability (P<0.0001), and quantity (P=0.01) were significantly lower in the DM group. Corneal sensitivity was also reduced in the DM group (P<0.001) and tear film stability was inversely associated with total neuropathy score (r=-0.29, P=0.03). Conclusion. The DM group exhibited significantly reduced tear film stability, secretion, and lipid layer quality relative to the age-matched control group. The negative correlation between tear film parameters and total neuropathy score suggests that ocular surface abnormalities occur in parallel with diabetic peripheral neuropathy. |
| format | Article |
| id | doaj-art-084faf96921c4e5f813aa2e8178e16e3 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-084faf96921c4e5f813aa2e8178e16e32025-08-20T03:55:32ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/848659848659Peripheral Neuropathy and Tear Film Dysfunction in Type 1 Diabetes MellitusStuti L. Misra0Dipika V. Patel1Charles N. J. McGhee2Monika Pradhan3Dean Kilfoyle4Geoffrey D. Braatvedt5Jennifer P. Craig6Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandDepartment of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandDepartment of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandDepartment of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandDepartment of Neurology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandDepartment of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandDepartment of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandPurpose. To compare tear film metrics in patients with type 1 diabetes mellitus (DM) and healthy controls and investigate the association between peripheral neuropathy and ocular surface quality. Methods. Dry eye symptoms were quantified in 53 patients with type 1 DM and 40 age-matched controls. Ocular examination included tear film lipid layer thickness grading, tear film stability and quantity measurement, and retinal photography. DM individuals additionally underwent a detailed neuropathy assessment. Results. Neither mean age nor dry eye symptom scores differed significantly between the DM and control groups (P=0.12 and P=0.33, resp.). Tear lipid thickness (P=0.02), stability (P<0.0001), and quantity (P=0.01) were significantly lower in the DM group. Corneal sensitivity was also reduced in the DM group (P<0.001) and tear film stability was inversely associated with total neuropathy score (r=-0.29, P=0.03). Conclusion. The DM group exhibited significantly reduced tear film stability, secretion, and lipid layer quality relative to the age-matched control group. The negative correlation between tear film parameters and total neuropathy score suggests that ocular surface abnormalities occur in parallel with diabetic peripheral neuropathy.http://dx.doi.org/10.1155/2014/848659 |
| spellingShingle | Stuti L. Misra Dipika V. Patel Charles N. J. McGhee Monika Pradhan Dean Kilfoyle Geoffrey D. Braatvedt Jennifer P. Craig Peripheral Neuropathy and Tear Film Dysfunction in Type 1 Diabetes Mellitus Journal of Diabetes Research |
| title | Peripheral Neuropathy and Tear Film Dysfunction in Type 1 Diabetes Mellitus |
| title_full | Peripheral Neuropathy and Tear Film Dysfunction in Type 1 Diabetes Mellitus |
| title_fullStr | Peripheral Neuropathy and Tear Film Dysfunction in Type 1 Diabetes Mellitus |
| title_full_unstemmed | Peripheral Neuropathy and Tear Film Dysfunction in Type 1 Diabetes Mellitus |
| title_short | Peripheral Neuropathy and Tear Film Dysfunction in Type 1 Diabetes Mellitus |
| title_sort | peripheral neuropathy and tear film dysfunction in type 1 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2014/848659 |
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