Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells

Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells

Abstract Liver fibrosis is a leading cause of liver-related mortality worldwide, yet effective therapies remain limited. Mesenchymal stem cells (MSCs) have recently shown promise in treating liver fibrosis due to their anti-inflammatory and anti-fibrotic properties. However, the precise molecular me...

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Bibliographic Details
Main Authors: Zheng Wang, Mengqin Yuan, Lichao Yao, Zhiyu Xiong, Kai Dai, Pingji Liu, Ping Chen, Muhua Sun, Kan Shu, Yuchen Xia, Yingan Jiang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Online Access:https://doi.org/10.1186/s12951-025-03291-4
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