Thermal Hazard Study on the Synthesis of 3-Amino-4-nitrofurazan

The synthesis of 3-amino-4-nitrofurazan (ANF), a critical precursor for various monofurazan derivatives, involves the oxidation of 3,4-diaminofurazan (DAF) using an oxidizing system of CH3SO3H-H2O2-Na2WO4. This complex process produces two primary outcomes: the desired product ANF and a by-product,...

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Main Authors: Liping Chen, Jiayu Lyu, Juan Zhou, Meiling Liu, Zichao Guo, Wanghua Chen
Format: Article
Language:English
Published: AIDIC Servizi S.r.l. 2025-06-01
Series:Chemical Engineering Transactions
Online Access:https://www.cetjournal.it/index.php/cet/article/view/15168
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author Liping Chen
Jiayu Lyu
Juan Zhou
Meiling Liu
Zichao Guo
Wanghua Chen
author_facet Liping Chen
Jiayu Lyu
Juan Zhou
Meiling Liu
Zichao Guo
Wanghua Chen
author_sort Liping Chen
collection DOAJ
description The synthesis of 3-amino-4-nitrofurazan (ANF), a critical precursor for various monofurazan derivatives, involves the oxidation of 3,4-diaminofurazan (DAF) using an oxidizing system of CH3SO3H-H2O2-Na2WO4. This complex process produces two primary outcomes: the desired product ANF and a by-product, 3,3'-diamino-4,4'-azofuroxide (DAOAF). To evaluate the thermal hazards associated with this reaction, reaction calorimetry (RC1) was utilized to study the thermal behavior, followed by separation, washing, extraction, evaporation, and drying of the final reaction mixture, resulting in two solid products: a filter cake and the dried filtrate. The yields of ANF and DAOAF were quantified through HPLC analysis. Kinetic parameters were derived using a five-step reaction model based on heat generation rate data. Findings indicate that the fourth reaction step, responsible for ANF formation, demonstrated the highest heat release at 599.9 kJ·mol-1 with an activation energy of 93.0 kJ·mol -1. The Maximum Temperature of Synthesis Reaction (MTSR) was established at 55°C, while adiabatic calorimetry suggested limited thermal stability, with a TD24 of 23°C. Consequently, Dr. Stoessel’s thermal runaway classification was expanded from five to six classes to assess the thermal risks better, categorizing the oxidation reaction as Class 6.
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issn 2283-9216
language English
publishDate 2025-06-01
publisher AIDIC Servizi S.r.l.
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series Chemical Engineering Transactions
spelling doaj-art-0845fcc49a474e5eb66fa2683469e42c2025-08-20T03:14:47ZengAIDIC Servizi S.r.l.Chemical Engineering Transactions2283-92162025-06-01116Thermal Hazard Study on the Synthesis of 3-Amino-4-nitrofurazanLiping ChenJiayu LyuJuan ZhouMeiling LiuZichao GuoWanghua ChenThe synthesis of 3-amino-4-nitrofurazan (ANF), a critical precursor for various monofurazan derivatives, involves the oxidation of 3,4-diaminofurazan (DAF) using an oxidizing system of CH3SO3H-H2O2-Na2WO4. This complex process produces two primary outcomes: the desired product ANF and a by-product, 3,3'-diamino-4,4'-azofuroxide (DAOAF). To evaluate the thermal hazards associated with this reaction, reaction calorimetry (RC1) was utilized to study the thermal behavior, followed by separation, washing, extraction, evaporation, and drying of the final reaction mixture, resulting in two solid products: a filter cake and the dried filtrate. The yields of ANF and DAOAF were quantified through HPLC analysis. Kinetic parameters were derived using a five-step reaction model based on heat generation rate data. Findings indicate that the fourth reaction step, responsible for ANF formation, demonstrated the highest heat release at 599.9 kJ·mol-1 with an activation energy of 93.0 kJ·mol -1. The Maximum Temperature of Synthesis Reaction (MTSR) was established at 55°C, while adiabatic calorimetry suggested limited thermal stability, with a TD24 of 23°C. Consequently, Dr. Stoessel’s thermal runaway classification was expanded from five to six classes to assess the thermal risks better, categorizing the oxidation reaction as Class 6.https://www.cetjournal.it/index.php/cet/article/view/15168
spellingShingle Liping Chen
Jiayu Lyu
Juan Zhou
Meiling Liu
Zichao Guo
Wanghua Chen
Thermal Hazard Study on the Synthesis of 3-Amino-4-nitrofurazan
Chemical Engineering Transactions
title Thermal Hazard Study on the Synthesis of 3-Amino-4-nitrofurazan
title_full Thermal Hazard Study on the Synthesis of 3-Amino-4-nitrofurazan
title_fullStr Thermal Hazard Study on the Synthesis of 3-Amino-4-nitrofurazan
title_full_unstemmed Thermal Hazard Study on the Synthesis of 3-Amino-4-nitrofurazan
title_short Thermal Hazard Study on the Synthesis of 3-Amino-4-nitrofurazan
title_sort thermal hazard study on the synthesis of 3 amino 4 nitrofurazan
url https://www.cetjournal.it/index.php/cet/article/view/15168
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