Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads
A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their t...
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| Format: | Article |
| Language: | English |
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Sciendo
2020-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2020-0037 |
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| author | Vlachou Marilena Siamidi Angeliki Goula Efstratia Georgas Panagiotis Pippa Natassa Karalis Vangelis Sentoukas Theodore Pispas Stergios |
| author_facet | Vlachou Marilena Siamidi Angeliki Goula Efstratia Georgas Panagiotis Pippa Natassa Karalis Vangelis Sentoukas Theodore Pispas Stergios |
| author_sort | Vlachou Marilena |
| collection | DOAJ |
| description | A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their thermal degradation properties. It has been found that the release of MLT from the beads was reversibly proportional to the extent of their expansion, which depends on the molecular mass/viscosity of the biopolymers present in the beads; the higher the molecular mass/viscosity of the hydrogels the greater the beads swelling and the less the MLT’s release. Thermogravimetric analysis (TGA) data support the presence of the components in the hybrid hydrogel beads and elucidate their effects on the thermal stability of the systems. Thus, the physicochemical properties of the biopolymers used, along with their stereoelectronic features modulate the release of MLT from the beads, providing formulations able to treat sleep onset related problems or dysfunctions arising from poor sleep maintenance. |
| format | Article |
| id | doaj-art-08400694e1b14382991ae46d9d0ee395 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-08400694e1b14382991ae46d9d0ee3952025-02-02T17:01:55ZengSciendoActa Pharmaceutica1846-95582020-12-0170452753810.2478/acph-2020-0037acph-2020-0037Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beadsVlachou Marilena0Siamidi Angeliki1Goula Efstratia2Georgas Panagiotis3Pippa Natassa4Karalis Vangelis5Sentoukas Theodore6Pispas Stergios7Section of Pharmaceutical Technology Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, GreeceSection of Pharmaceutical Technology Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, GreeceSection of Pharmaceutical Technology Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, GreeceSection of Pharmaceutical Technology Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, GreeceSection of Pharmaceutical Technology Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, GreeceSection of Pharmaceutical Technology Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, GreeceTheoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 11635 Athens, GreeceTheoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 11635 Athens, GreeceA variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their thermal degradation properties. It has been found that the release of MLT from the beads was reversibly proportional to the extent of their expansion, which depends on the molecular mass/viscosity of the biopolymers present in the beads; the higher the molecular mass/viscosity of the hydrogels the greater the beads swelling and the less the MLT’s release. Thermogravimetric analysis (TGA) data support the presence of the components in the hybrid hydrogel beads and elucidate their effects on the thermal stability of the systems. Thus, the physicochemical properties of the biopolymers used, along with their stereoelectronic features modulate the release of MLT from the beads, providing formulations able to treat sleep onset related problems or dysfunctions arising from poor sleep maintenance.https://doi.org/10.2478/acph-2020-0037melatoninhydrogelscalcium alginate beadsswelling behaviorthermogravimetric analysisin vitro release |
| spellingShingle | Vlachou Marilena Siamidi Angeliki Goula Efstratia Georgas Panagiotis Pippa Natassa Karalis Vangelis Sentoukas Theodore Pispas Stergios Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads Acta Pharmaceutica melatonin hydrogels calcium alginate beads swelling behavior thermogravimetric analysis in vitro release |
| title | Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads |
| title_full | Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads |
| title_fullStr | Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads |
| title_full_unstemmed | Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads |
| title_short | Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads |
| title_sort | probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads |
| topic | melatonin hydrogels calcium alginate beads swelling behavior thermogravimetric analysis in vitro release |
| url | https://doi.org/10.2478/acph-2020-0037 |
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