Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment
Abstract Background To determine the feasibility, acceptability, and preliminary efficacy of a 6-month tailored non-linear progressive physical activity intervention (PAI) for lymphoma patients undergoing chemotherapy. Methods Patients newly diagnosed with lymphoma (non-Hodgkin (NHL) or Hodgkin (HL)...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Pilot and Feasibility Studies |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40814-024-01580-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594950787694592 |
|---|---|
| author | Juliana V. Costa Alexander R. Lucas Shannon L. Mihalko Peter H. Brubaker Alexandra Marshall Brianna Leitzelar Brianna R. Wolle Samuel Norton R. Lee Franco Jeremy Via Victor Yazbeck Rakhee Vaidya Mary Beth Seegars Ralph D’Agostino Lynne Wagner W. Gregory Hundley |
| author_facet | Juliana V. Costa Alexander R. Lucas Shannon L. Mihalko Peter H. Brubaker Alexandra Marshall Brianna Leitzelar Brianna R. Wolle Samuel Norton R. Lee Franco Jeremy Via Victor Yazbeck Rakhee Vaidya Mary Beth Seegars Ralph D’Agostino Lynne Wagner W. Gregory Hundley |
| author_sort | Juliana V. Costa |
| collection | DOAJ |
| description | Abstract Background To determine the feasibility, acceptability, and preliminary efficacy of a 6-month tailored non-linear progressive physical activity intervention (PAI) for lymphoma patients undergoing chemotherapy. Methods Patients newly diagnosed with lymphoma (non-Hodgkin (NHL) or Hodgkin (HL)) were randomized into the PAI or healthy living intervention (HLI) control (2:1). Feasibility was assessed by examining accrual, adherence, and retention rates. Participants completed assessments of exercise capacity (VO2 peak and 6-min walk distance (6MWD)), objective and self-reported levels of physical activity, MRI-derived cardiovascular functioning (Left Ventricular Ejection Fraction [LVEF], stroke volume, and cardiac output), and self-reported health-related and disease-specific quality of life and self-efficacy for exercise at baseline, 3, and 6 months. Results One hundred and forty-five individuals were screened with 23 of 84 eligible patients agreeing to participate (27%). Three participants withdrew before baseline testing. Out of the 20 participants randomized to the PAI (n = 13) and HLI groups (n = 7), 18 completed the intervention resulting in an overall retention rate of 78%. The adherence rates to the PAI and HLI were 85% and 87%, respectively. One non-serious adverse event was registered. VO2 peak ranged from 15.5–28.0 ml/kg/min at baseline and participants in both groups improved by 6 months. Physical activity levels and cardiovascular function were reduced prior to treatment but did not deteriorate further. Conclusions Implementing a tailored PAI in adults with lymphoma during active treatment is feasible, was well received by participants and shows preliminary efficacy for limiting a decline in function during treatment. Potential Implications for Cancer Survivors: Physical activity may be beneficial for improving exercise capacity and health-related quality of life in patients undergoing chemotherapy. Trial registration #NCT01719562 ClinicalTrials.gov. Registered July 2, 2019—retrospectively registered. |
| format | Article |
| id | doaj-art-083fdebbc6ed4223841e21db4c628fdb |
| institution | Kabale University |
| issn | 2055-5784 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Pilot and Feasibility Studies |
| spelling | doaj-art-083fdebbc6ed4223841e21db4c628fdb2025-01-19T12:10:48ZengBMCPilot and Feasibility Studies2055-57842025-01-0111111210.1186/s40814-024-01580-7Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatmentJuliana V. Costa0Alexander R. Lucas1Shannon L. Mihalko2Peter H. Brubaker3Alexandra Marshall4Brianna Leitzelar5Brianna R. Wolle6Samuel Norton7R. Lee Franco8Jeremy Via9Victor Yazbeck10Rakhee Vaidya11Mary Beth Seegars12Ralph D’Agostino13Lynne Wagner14W. Gregory Hundley15Department of Health and Exercise Science, Wake Forest UniversityDepartment of Internal Medicine - Cardiology, Virginia Commonwealth UniversityDepartment of Health and Exercise Science, Wake Forest UniversityDepartment of Health and Exercise Science, Wake Forest UniversityDepartment of Internal Medicine - Cardiology, Virginia Commonwealth UniversityDepartment of Social Science and Health Policy, Wake Forest University School of MedicineDepartment of Health and Exercise Science, Wake Forest UniversityDepartment of Health and Exercise Science, Wake Forest UniversityDepartment of Kinesiology and Health Sciences, Virginia Commonwealth UniversityDepartment of Kinesiology and Health Sciences, Virginia Commonwealth UniversityMassey Cancer Center, Virginia Commonwealth UniversityDepartment of Internal Medicine (Section On Oncology), Wake Forest School of MedicineDepartment of Internal Medicine (Section On Oncology), Wake Forest School of MedicineDepartment of Biostatistical Sciences, Wake Forest School of MedicineDepartment Of Health Policy and Management, University of North Carolina Gillings School of Global Public HealthDepartment of Internal Medicine - Cardiology, Virginia Commonwealth UniversityAbstract Background To determine the feasibility, acceptability, and preliminary efficacy of a 6-month tailored non-linear progressive physical activity intervention (PAI) for lymphoma patients undergoing chemotherapy. Methods Patients newly diagnosed with lymphoma (non-Hodgkin (NHL) or Hodgkin (HL)) were randomized into the PAI or healthy living intervention (HLI) control (2:1). Feasibility was assessed by examining accrual, adherence, and retention rates. Participants completed assessments of exercise capacity (VO2 peak and 6-min walk distance (6MWD)), objective and self-reported levels of physical activity, MRI-derived cardiovascular functioning (Left Ventricular Ejection Fraction [LVEF], stroke volume, and cardiac output), and self-reported health-related and disease-specific quality of life and self-efficacy for exercise at baseline, 3, and 6 months. Results One hundred and forty-five individuals were screened with 23 of 84 eligible patients agreeing to participate (27%). Three participants withdrew before baseline testing. Out of the 20 participants randomized to the PAI (n = 13) and HLI groups (n = 7), 18 completed the intervention resulting in an overall retention rate of 78%. The adherence rates to the PAI and HLI were 85% and 87%, respectively. One non-serious adverse event was registered. VO2 peak ranged from 15.5–28.0 ml/kg/min at baseline and participants in both groups improved by 6 months. Physical activity levels and cardiovascular function were reduced prior to treatment but did not deteriorate further. Conclusions Implementing a tailored PAI in adults with lymphoma during active treatment is feasible, was well received by participants and shows preliminary efficacy for limiting a decline in function during treatment. Potential Implications for Cancer Survivors: Physical activity may be beneficial for improving exercise capacity and health-related quality of life in patients undergoing chemotherapy. Trial registration #NCT01719562 ClinicalTrials.gov. Registered July 2, 2019—retrospectively registered.https://doi.org/10.1186/s40814-024-01580-7Exercise capacityPhysical activityLymphomaCardiotoxicityHealth-related quality of lifeRandomized controlled pilot trial |
| spellingShingle | Juliana V. Costa Alexander R. Lucas Shannon L. Mihalko Peter H. Brubaker Alexandra Marshall Brianna Leitzelar Brianna R. Wolle Samuel Norton R. Lee Franco Jeremy Via Victor Yazbeck Rakhee Vaidya Mary Beth Seegars Ralph D’Agostino Lynne Wagner W. Gregory Hundley Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment Pilot and Feasibility Studies Exercise capacity Physical activity Lymphoma Cardiotoxicity Health-related quality of life Randomized controlled pilot trial |
| title | Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment |
| title_full | Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment |
| title_fullStr | Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment |
| title_full_unstemmed | Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment |
| title_short | Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment |
| title_sort | feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment |
| topic | Exercise capacity Physical activity Lymphoma Cardiotoxicity Health-related quality of life Randomized controlled pilot trial |
| url | https://doi.org/10.1186/s40814-024-01580-7 |
| work_keys_str_mv | AT julianavcosta feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT alexanderrlucas feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT shannonlmihalko feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT peterhbrubaker feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT alexandramarshall feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT briannaleitzelar feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT briannarwolle feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT samuelnorton feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT rleefranco feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT jeremyvia feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT victoryazbeck feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT rakheevaidya feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT marybethseegars feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT ralphdagostino feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT lynnewagner feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment AT wgregoryhundley feasibilityandpreliminaryefficacyofaphysicalactivityinterventioninadultswithlymphomaundergoingtreatment |