In situ osteogenic activation of mesenchymal stem cells by the blood clot biomimetic mechanical microenvironment

In situ osteogenic activation of mesenchymal stem cells by the blood clot biomimetic mechanical microenvironment

Abstract Blood clots (BCs) play a crucial biomechanical role in promoting osteogenesis and regulating mesenchymal stem cell (MSC) function and fate. This study shows that BC formation enhances MSC osteogenesis by activating Itgb1/Fak-mediated focal adhesion and subsequent Runx2-mediated bone regener...

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Bibliographic Details
Main Authors: Wangxiao He, Fan Ding, Liqiang Zhang, Wenjia Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56513-6
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