Neurodegenerative Biomarkers in Multiple Sclerosis: At the Interface Between Research and Clinical Practice

Neurodegenerative Biomarkers in Multiple Sclerosis: At the Interface Between Research and Clinical Practice

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While the inflammatory components of MS have been extensively studied, the progressive neurodegenerative aspect remains a critical fac...

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Main Authors: Alin Ciubotaru, Mădălina Irina Smihor, Cristina Grosu, Daniel Alexa, Roxana Covali, Robert-Constantin Anicăi, Ioana Păvăleanu, Andrei Ionuț Cucu, Amelian Mădălin Bobu, Cristina Mihaela Ghiciuc, Emilian Bogdan Ignat
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Diagnostics
Subjects:
multiple sclerosis
neurofilaments
neurodegeneration
kynurenines
Online Access:https://www.mdpi.com/2075-4418/15/9/1178
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Summary:Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While the inflammatory components of MS have been extensively studied, the progressive neurodegenerative aspect remains a critical factor contributing to long-term disability. Therefore, the identification and validation of biomarkers associated with neurodegenerative processes are essential for improved diagnosis, prognosis, and treatment monitoring. This review explores cerebrospinal fluid (CSF) and blood-based biomarkers, including neurofilaments, lipid markers, kynurenines, and other molecular indicators that provide insights into neurodegeneration in MS.
ISSN:2075-4418

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