Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its Background
In the experiment on the white Wistar female rats (222 animals), the osteoprotective effect of enalapril and losartan was studied on experimental models of osteoporosis and osteoporotic fractures. It was revealed that in rats after ovariectomy, the endothelial dysfunction of microcirculation vessels...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2013/325693 |
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| author | D. S. R. Rajkumar A. V. Faitelson O. S. Gudyrev G. M. Dubrovin M. V. Pokrovski A. V. Ivanov |
| author_facet | D. S. R. Rajkumar A. V. Faitelson O. S. Gudyrev G. M. Dubrovin M. V. Pokrovski A. V. Ivanov |
| author_sort | D. S. R. Rajkumar |
| collection | DOAJ |
| description | In the experiment on the white Wistar female rats (222 animals), the osteoprotective effect of enalapril and losartan was studied on experimental models of osteoporosis and osteoporotic fractures. It was revealed that in rats after ovariectomy, the endothelial dysfunction of microcirculation vessels of osteal tissue develops, resulting in occurrence of osteoporosis and delay of consolidation of experimental fractures. Enalapril and losartan prevented the reduction of microcirculation in bone, which was reflected in slowing the thinning of bone trabeculae and in preventing the occurrence of these microfractures, as well as increasing quality of experimental fractures healing. |
| format | Article |
| id | doaj-art-0833f1afb683461383de6916d9876c7d |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-0833f1afb683461383de6916d9876c7d2025-02-03T05:47:01ZengWileyJournal of Osteoporosis2090-80592042-00642013-01-01201310.1155/2013/325693325693Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its BackgroundD. S. R. Rajkumar0A. V. Faitelson1O. S. Gudyrev2G. M. Dubrovin3M. V. Pokrovski4A. V. Ivanov5Department of Traumatology and Orthopedics and Battle Field Surgery, Kursk State Medical University, Karl Marx Street, Kursk 305 004, RussiaDepartment of Traumatology and Orthopedics and Battle Field Surgery, Kursk State Medical University, Karl Marx Street, Kursk 305 004, RussiaDepartment of Clinical Pharmacology, Kursk State Medical University, Karl Marx Street, Kursk 305 004, RussiaDepartment of Traumatology and Orthopedics and Battle Field Surgery, Kursk State Medical University, Karl Marx Street, Kursk 305 004, RussiaDepartment of Pharmacology, Kursk State Medical University, Karl Marx Street, Kursk 305 004, RussiaDepartment of Histology, Cytology and Embryology, Kursk State Medical University, Karl Marx Street, Kursk 305 004, RussiaIn the experiment on the white Wistar female rats (222 animals), the osteoprotective effect of enalapril and losartan was studied on experimental models of osteoporosis and osteoporotic fractures. It was revealed that in rats after ovariectomy, the endothelial dysfunction of microcirculation vessels of osteal tissue develops, resulting in occurrence of osteoporosis and delay of consolidation of experimental fractures. Enalapril and losartan prevented the reduction of microcirculation in bone, which was reflected in slowing the thinning of bone trabeculae and in preventing the occurrence of these microfractures, as well as increasing quality of experimental fractures healing.http://dx.doi.org/10.1155/2013/325693 |
| spellingShingle | D. S. R. Rajkumar A. V. Faitelson O. S. Gudyrev G. M. Dubrovin M. V. Pokrovski A. V. Ivanov Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its Background Journal of Osteoporosis |
| title | Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its Background |
| title_full | Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its Background |
| title_fullStr | Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its Background |
| title_full_unstemmed | Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its Background |
| title_short | Comparative Evaluation of Enalapril and Losartan in Pharmacological Correction of Experimental Osteoporosis and Fractures of Its Background |
| title_sort | comparative evaluation of enalapril and losartan in pharmacological correction of experimental osteoporosis and fractures of its background |
| url | http://dx.doi.org/10.1155/2013/325693 |
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