Study of the technological properties of excipients in the development of the composition of orally dispersible tablets
Introduction. The article presents the results of studying the technological properties of individual excipients widely used in the compositions of existing orally dispersed tablets (ODT) for subsequent planning a multifactorial experiment. Samples of excipients were analyzed according to such pharm...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2021-12-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/1100 |
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| author | I. D. Kasymov A. V. Basevich |
| author_facet | I. D. Kasymov A. V. Basevich |
| author_sort | I. D. Kasymov |
| collection | DOAJ |
| description | Introduction. The article presents the results of studying the technological properties of individual excipients widely used in the compositions of existing orally dispersed tablets (ODT) for subsequent planning a multifactorial experiment. Samples of excipients were analyzed according to such pharmacopoeial indicators as description, flowability, bulk density, compressibility, fractional composition, solubility in water.Aim. The aim of the work is to create a list and study the technological properties of candidate substances for the role of auxiliary substances in the composition being developed by the ODT.Materials and methods. The technological properties of excipient samples were studied according to the methods of the State Pharmacopoeia of the XIV edition using the flowability tester GTL (ERWEKA, Germany), the bulk density tester SVM 221 (ERWEKA, Germany), the tablet press PGR-10 (LabTools, Russia) and the tablet hardness tester TBH 125 TDP (ERWEKA, Germany).Results and discussion. As a result of the study, experimental data on the technological properties of excipient samples were collected, and the selected samples were compared according to pharmaceutical and technological indicators.Conclusion. In the course of the study, a list of auxiliary substances for the development of the composition of ODT was formed and studies of their technological properties were carried out. The obtained experimental data will allow to develop an optimal matrix of a multifactorial experiment for the development of the composition of ODT and justify the choice of excipients. |
| format | Article |
| id | doaj-art-0832030e05804da0bee963ce45a8efd9 |
| institution | Kabale University |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-0832030e05804da0bee963ce45a8efd92025-08-20T03:59:04ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492021-12-01104465310.33380/2305-2066-2021-10-4(1)-46-53907Study of the technological properties of excipients in the development of the composition of orally dispersible tabletsI. D. Kasymov0A. V. Basevich1Saint-Petersburg State Chemical and Pharmaceutical UniversitySaint-Petersburg State Chemical and Pharmaceutical UniversityIntroduction. The article presents the results of studying the technological properties of individual excipients widely used in the compositions of existing orally dispersed tablets (ODT) for subsequent planning a multifactorial experiment. Samples of excipients were analyzed according to such pharmacopoeial indicators as description, flowability, bulk density, compressibility, fractional composition, solubility in water.Aim. The aim of the work is to create a list and study the technological properties of candidate substances for the role of auxiliary substances in the composition being developed by the ODT.Materials and methods. The technological properties of excipient samples were studied according to the methods of the State Pharmacopoeia of the XIV edition using the flowability tester GTL (ERWEKA, Germany), the bulk density tester SVM 221 (ERWEKA, Germany), the tablet press PGR-10 (LabTools, Russia) and the tablet hardness tester TBH 125 TDP (ERWEKA, Germany).Results and discussion. As a result of the study, experimental data on the technological properties of excipient samples were collected, and the selected samples were compared according to pharmaceutical and technological indicators.Conclusion. In the course of the study, a list of auxiliary substances for the development of the composition of ODT was formed and studies of their technological properties were carried out. The obtained experimental data will allow to develop an optimal matrix of a multifactorial experiment for the development of the composition of ODT and justify the choice of excipients.https://www.pharmjournal.ru/jour/article/view/1100orally dispersible tabletsexcipientstechnological propertiesflowabilitybulk densitycompressibility |
| spellingShingle | I. D. Kasymov A. V. Basevich Study of the technological properties of excipients in the development of the composition of orally dispersible tablets Разработка и регистрация лекарственных средств orally dispersible tablets excipients technological properties flowability bulk density compressibility |
| title | Study of the technological properties of excipients in the development of the composition of orally dispersible tablets |
| title_full | Study of the technological properties of excipients in the development of the composition of orally dispersible tablets |
| title_fullStr | Study of the technological properties of excipients in the development of the composition of orally dispersible tablets |
| title_full_unstemmed | Study of the technological properties of excipients in the development of the composition of orally dispersible tablets |
| title_short | Study of the technological properties of excipients in the development of the composition of orally dispersible tablets |
| title_sort | study of the technological properties of excipients in the development of the composition of orally dispersible tablets |
| topic | orally dispersible tablets excipients technological properties flowability bulk density compressibility |
| url | https://www.pharmjournal.ru/jour/article/view/1100 |
| work_keys_str_mv | AT idkasymov studyofthetechnologicalpropertiesofexcipientsinthedevelopmentofthecompositionoforallydispersibletablets AT avbasevich studyofthetechnologicalpropertiesofexcipientsinthedevelopmentofthecompositionoforallydispersibletablets |