Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway
Abstract Globally, uveitis is a collection of intraocular inflammatory disorders that affect mainly the uvea, resulting in irreversible blindness and a heavy socioeconomic burden. Excessive autoimmune inflammation and oxidative stress are major drivers that contribute to the initiation and progressi...
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BMC
2025-02-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-024-03082-3 |
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| author | Weiwei Tang Xiaomin Huang Yun-Di Yi Fan Cao Manli Deng Jiawei Fan Zheng-Xuan Jiang Li-Ming Tao Xianwen Wang Lei Shi |
| author_facet | Weiwei Tang Xiaomin Huang Yun-Di Yi Fan Cao Manli Deng Jiawei Fan Zheng-Xuan Jiang Li-Ming Tao Xianwen Wang Lei Shi |
| author_sort | Weiwei Tang |
| collection | DOAJ |
| description | Abstract Globally, uveitis is a collection of intraocular inflammatory disorders that affect mainly the uvea, resulting in irreversible blindness and a heavy socioeconomic burden. Excessive autoimmune inflammation and oxidative stress are major drivers that contribute to the initiation and progression of uveitis. Nevertheless, current therapeutic methods for uveitis are limited and are accompanied by several serious adverse effects. Recently, nanotechnology-based antioxidant strategies have provided novel options for the treatment of ocular diseases. Although curcumin (CUR) has prominent antioxidant capacity and reactive oxygen species (ROS) scavenging ability, its low bioavailability and undetermined mechanisms limit its extensive application. This investigation demonstrated that esterified hyaluronic acid-curcumin nanoparticles (HA-CUR NPs) with superior aqueous dispersion exhibited exceptional antioxidant enzyme mimetic activity, incorporating superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and free radical scavenging ability. Further in vitro and in vivo experimental results validated the protective function of HA-CUR NPs against oxidative stress-induced damage and inflammatory responses, attenuated pathological progression, relieved microvascular damage, and regulated fundus blood flow in retinal vascular networks. This may be attributable to the specific ability of HA-CUR NPs to target the CD44 receptor and activate the Keap1/Nrf2/HO-1 signaling pathway, suggesting a potential mechanism. In summary, this study revealed that HA-CUR NPs, which are composed of a natural product and biomacromolecules with outstanding artificial antioxidant enzyme activities, may be novel agents for effectively and safely treating uveitis and other ROS-related diseases. |
| format | Article |
| id | doaj-art-082f20ac5beb454fbfc623359c86d397 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-082f20ac5beb454fbfc623359c86d3972025-02-09T12:52:59ZengBMCJournal of Nanobiotechnology1477-31552025-02-0123112010.1186/s12951-024-03082-3Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathwayWeiwei Tang0Xiaomin Huang1Yun-Di Yi2Fan Cao3Manli Deng4Jiawei Fan5Zheng-Xuan Jiang6Li-Ming Tao7Xianwen Wang8Lei Shi9Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical UniversityEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical SciencesDepartment of Ophthalmology, The Second Affiliated Hospital of Anhui Medical UniversityDepartment of Ophthalmology, The Second Affiliated Hospital of Anhui Medical UniversityEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical SciencesDepartment of Ophthalmology, The Second Affiliated Hospital of Anhui Medical UniversityDepartment of Ophthalmology, The Second Affiliated Hospital of Anhui Medical UniversityDepartment of Ophthalmology, The Second Affiliated Hospital of Anhui Medical UniversitySchool of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical UniversityDepartment of Ophthalmology, Anhui No. 2 Provincial People’s HospitalAbstract Globally, uveitis is a collection of intraocular inflammatory disorders that affect mainly the uvea, resulting in irreversible blindness and a heavy socioeconomic burden. Excessive autoimmune inflammation and oxidative stress are major drivers that contribute to the initiation and progression of uveitis. Nevertheless, current therapeutic methods for uveitis are limited and are accompanied by several serious adverse effects. Recently, nanotechnology-based antioxidant strategies have provided novel options for the treatment of ocular diseases. Although curcumin (CUR) has prominent antioxidant capacity and reactive oxygen species (ROS) scavenging ability, its low bioavailability and undetermined mechanisms limit its extensive application. This investigation demonstrated that esterified hyaluronic acid-curcumin nanoparticles (HA-CUR NPs) with superior aqueous dispersion exhibited exceptional antioxidant enzyme mimetic activity, incorporating superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and free radical scavenging ability. Further in vitro and in vivo experimental results validated the protective function of HA-CUR NPs against oxidative stress-induced damage and inflammatory responses, attenuated pathological progression, relieved microvascular damage, and regulated fundus blood flow in retinal vascular networks. This may be attributable to the specific ability of HA-CUR NPs to target the CD44 receptor and activate the Keap1/Nrf2/HO-1 signaling pathway, suggesting a potential mechanism. In summary, this study revealed that HA-CUR NPs, which are composed of a natural product and biomacromolecules with outstanding artificial antioxidant enzyme activities, may be novel agents for effectively and safely treating uveitis and other ROS-related diseases.https://doi.org/10.1186/s12951-024-03082-3Hyaluronic acidCurcuminNanoparticlesExperimental autoimmune uveitisOxidative stress |
| spellingShingle | Weiwei Tang Xiaomin Huang Yun-Di Yi Fan Cao Manli Deng Jiawei Fan Zheng-Xuan Jiang Li-Ming Tao Xianwen Wang Lei Shi Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway Journal of Nanobiotechnology Hyaluronic acid Curcumin Nanoparticles Experimental autoimmune uveitis Oxidative stress |
| title | Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway |
| title_full | Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway |
| title_fullStr | Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway |
| title_full_unstemmed | Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway |
| title_short | Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway |
| title_sort | hyaluronic acid curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the keap1 nrf2 ho 1 signaling pathway |
| topic | Hyaluronic acid Curcumin Nanoparticles Experimental autoimmune uveitis Oxidative stress |
| url | https://doi.org/10.1186/s12951-024-03082-3 |
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