Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs

Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs

<b>Background/Objectives</b>: N-acetyl-galactosamine small interfering RNAs (GalNAc-siRNA) are an emerging class of drugs due to their durable knockdown of disease-related proteins. Direct conjugation of GalNAc onto the siRNA enables targeted uptake into hepatocytes via GalNAc recognitio...

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Bibliographic Details
Main Authors: Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceutics
Subjects:
siRNA
physiologically based pharmacokinetic modeling
PK-Sim
ASGPR
RISC
GalNAc
Online Access:https://www.mdpi.com/1999-4923/17/1/69
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